A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Walsh, Wang, Ware, Washington, Weaver, Webber, Weiner, Wickliffe, Wiese, Williams , Wimley, Wright , X. Wu, G. Wu
John W. Walsh, M.D.

Professor of Neurosurgery
Chief of Pediatric Neurosurgery
TCC Associate Member
jwalshmd@tulane.edu
(504) 988-5565, (504) 988-5793 fax
1430 Tulane Ave., Box SL-47, New Orleans, LA 70112-2699

He Wang He Wang, Ph.D.

Assistant Professor of Environmental Health Sciences
TCC Program Member
hwang2@tulane.edu
(504) 988-1081, (504) 988-1726 fax
1430 Tulane Ave., Box TW-2100, New Orleans, LA 70112-2699

 

 

 

Biographical Narrative:

Dr. Wang received his Ph.D. from the University of Sydney in 1998 and conducted research as a scientific officer at the University of New South Wales from 1998-2003. From 2003-2007, he was senior lecturer at the University of Adelaide. His main research interests are the mutagenic/carcinogenic effects of airborne particles, inflammatory reactions caused by environmental factors, and possible consequences of the inflammation.

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Marcus L. WareMarcus L. Ware, M.D., Ph.D.

Assistant Professor of Neurosurgery
TCC Associate Member
mware@tulane.edu
(504) 988-5561, (504) 988-1731 fax
1430 Tulane Ave., Box SL-47, New Orleans, LA 70112-2699

 

 

Biographical Narrative:

Dr. Marcus L. Ware attended Tougaloo College in Jackson, Mississippi, where he majored in chemistry and graduated with a B.S. in 1993. After college, he attended Harvard Medical School and was a student in the Harvard-MIT Health Sciences and Technology Program (HST) and the MD/PhD Program. Dr. Ware completed his thesis work in the laboratory of Christopher Walsh, MD, PhD, studying molecular events in the development of the brain. After graduating in 2000, he trained as a resident in the Department of Neurological Surgery at the University of California, San Francisco. As a resident, he became interested in genes required for brain tumor formation. In 2004, he obtained a National Research Service Award from the National Institutes of Health under the mentorship of Burt Feuerstein, M.D., Ph.D., and studied genetic aberrations in gliomas.

Recent Publications:

  • Ware ML, Hirose Y, Scheithauer BW, Yeh RF, Mayo MC, Smith JS, Chang S, Cha S, Tihan T, Geuerstein BG. Genetic aberrations in gliomatosis cerebri. Neurosurgery, 60(1): 150-158, 2007.
  • Ware ML, Larson DA, Sneed PK, Wara WW, McDermott MW. Surgical resection and brachytherapy for recurrent atypical and malignant meningioma. Neurosurgery, 54: 55-63, 2004.
  • Ware ML, Reid CB, Tavazoie S, Walsh C. Coexistence of widespread and large radial clones in early embryonic ferret cortex. Cerebral Cortex, 9: 636-645, 1999.
  • Ware ML, Fox JW, Gonzalez JL, Davis NM, Lambert de Rouvroit C, Russo CJ, Chua SC Jr., Goffinet AM, Walsh CA. Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse. Neuron, 19: 239-249, 1997.

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Alexander Washington Alexander Washington, M.D.

Clinical Associate Professor of Medicine
Section of Hematology/Medical Oncology
TCC Associate Member
awashin2@tulane.edu
(504) 988-2967
1430 Tulane Ave., Box SL-78, New Orleans, LA 70112-2699

 

 

Michael Weaver, M.D.

Associate Professor of Surgery
mweaver@tulane.edu
(504) 988-7520
1430 Tulane Ave., Box SL-22, New Orleans, LA 70112-2699

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Larry S. Webber Larry S. Webber, Ph.D.

Professor of Biostatistics, Tulane School of Public Health and Tropical Medicine
TCC Contributing Member
lwebber@tulane.edu
(504) 988-5164, (504) 988-1706 fax
1430 Tulane Ave., Box SL-18, New Orleans, LA 70112-2699
Homepage on the Epidemiology website:
http://www.biostatistics.tulane.edu/bio_pages/faculty_bio/webber.html


Biographical Narrative:

Dr. Webber received his B.S. in Mathematics from Louisiana State University at Baton Rouge in 1967. After attending Graduate School at Louisiana State University Health Sciences Center, he entered Yale University in 1967 where he completed an M.Phil. degree in Biometry and a Ph.D. degree in Biometry. Dr. Webber was appointed by the National Research Council as a Statistician with the Atomic Bomb Casualty Commission (now the Radiation Effects Research Foundation) from 1972-1974. In 1974 he took a faculty position with Louisiana State University Health Sciences Center as Head of the Planning and Analysis Core for the Bogalusa Heart Study, a long-term epidemiological investigation of cardiovascular risk factors and risk behaviors. He reached the rank of Professor in the Departments of Medicine and Biometry and Genetics in 1984. Since 1991 Dr. Webber has served as Professor and Chair, Department of Biostatistics at Tulane University School of Public Health and Tropical Medicine. He has published over 270 papers as principal author or co-author. He is a reviewer for several epidemiological and public health journals and has served on various NIH review panels. The primary focus of his research is the epidemiology of cardiovascular risk factors and risk behaviors during childhood and adolescence. Since 1987 Dr. Webber has been associated with several school-based intervention models to reduce risk factors and alter risk behaviors. Dr. Webber serves as the Principal Investigator for the Louisiana site of two multi-site clinical trials, the Child and Adolescent Trial of Cardiovascular Health (CATCH) and the Trial of Activity for Adolescent Girls (TAAG). The former is a multi-component program to reduce dietary fat, increase physical activity and reduce the onset of tobacco use in elementary school children. The latter is a multi-site trial to increase opportunities for and participation in physical activity for middle school-age girls. Dr. Webber serves as Chair of the Steering Committee for the TAAG trial.


Recent Publications:

  • Webber LS, Osganian SK, Feldman HA, Wu M, McKenzie TL, Nichaman M, Lytle LA, Edmundson E, Cutter J, Nader PR, Luepker RV. (1996) Cardiovascular risk factors in children after a two and one-half year intervention: The CATCH Study. Prev Med 25: 432-41.
  • Greenlund KJ, Webber LS, Srinivasan S, Wattigney W, Johnson C, Berenson GS. (1997) Association of oral contraceptive use with serum lipids and lipoproteins in young women. The Bogalusa Heart Study. Ann Epidemiol 7: 561-7.
  • Nader PR, Stone EJ, Lytle LA, Perry CL, Osganian SK, Kelder S, Webber LS, J.P. Elder, D. Montgomery, Feldman HA, Wu M, Johnson C, Parcel GS, Luepker RV. (1999) Three-year maintenance of improved diet and physical activity: the CATCH cohort. Arch Ped Adol Med 153: 695-704.
  • Osganian SK, Stampfer MJ, Spiegelmann D, Rimm E, Cutter JA, Feldman HA, Montgomery DH, Webber LS, Lytle LA, Bausserman L, Nader PR. (1999) Distribution of and factors associated with serum homocysteine levels in US School Children: The Child and Adolescent Trial for Cardiovascular Health. JAMA 281: 1189-96.
  • Dwyer JT, Stone EJ, Yang M, Webber LS, Must A, Feldman HA, Nader PR, Perry CL, Parcel GS (on behalf of the CATCH Cooperative Research Group). (2000) Prevalence of overweight and obesity in a multiethnic pediatric population: findings from the CATCH Study. J Am Diet Assoc 100: 1149-56.
  • Johnson CC, Myers L, Webber LS, Boris NW. Profiles of the adolescent smoker: models of tobacco use among 9th grade high school students: Acadiana Coalition of Teens against Tobacco (ACTT). Prev Med Sep;39(3):551-8 (2004)

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Roy S. Weiner Roy S. Weiner, M.D.
Associate Dean for Clinical Research and Education
Associate Director of Clinical Research for Tulane Cancer Center
Professor of Medicine, Pediatrics, and Epidemiology
Edward G. Schlieder Educational Foundation Chair in Medical Oncology
rweiner@tulane.edu
(504) 988-6061, (504) 988-6077 fax
1430 Tulane Ave., Box SL-68, New Orleans, LA 70112-2699

Biographical Narrative:

Dr. Weiner completed his undergraduate degree at Williams College, majoring in German and Biology. He received his M.D. in 1967 from SUNY at Brooklyn with a research emphasis in immunology. He trained in internal medicine at Johns Hopkins Hospital and at the Hospitals of the University of California in San Francisco. After a fellowship in medical oncology and immunology as a Staff Associate at the NIH, he completed a second post-doctoral fellowship in cellular immunology and immunotherapy at l'Institut de Cancerologie et d'Immunogenetique in Villejuif, France. Dr. Weiner taught at Harvard Medical School as Assistant Professor of Medicine and Research Associate at the Dana Farber Cancer Institute and the Brigham and Womens Hospital prior to joining the faculty at the University of Florida as Associate Professor of Medicine, Microbiology and Immunology and Chief, Division of Medical Oncology in 1976. He was promoted to Professor in 1981 and in 1987 began serving as the American Cancer Society Professor of Clinical Oncology. Dr. Weiner's basic research contributions are focused on human hematopoeitic stem cell physiology, cell separation and stem cell cryopreservation. The methods he developed for freezing and thawing human mononuclear cells are used widely today in basic research and in clinical stem cell transplantation. His clinical research contributed to the modern multi-drug treatment of adult leukemia and, more recently, the multimodality therapy of locally advanced breast cancer. He has published more than 140 scientific papers in peer-reviewed journals, many invited papers, and has edited several books. He is on the editorial boards of several scholarly journals and has served the AACR, ASCO, and ASH in leadership positions. Dr. Weiner began working at Tulane University in 1993 as the Edward G. Schleider Educational Foundation Professor of Medical Oncology and founding Director of the Tulane Cancer Center. Responding to the critical needs of the region, (Louisiana has the 3rd highest cancer death rate in the U.S.), Dr. Weiner has concentrated his clinical energies in community programs designed to promote early detection of cancer, especially breast cancer. He instituted the region's first comprehensive breast diagnostic center and treatment clinic, and has developed a community-based clinical research network spanning the Gulf Coast and the entire State of Louisiana.


Recent Publications:

  • Miller AM, Conley NS, Allen B, Hoover DL, Weiner RS. (1994) Bleomycin-induced differentiation of a human monoblast cell line U937. Cancer Res Ther and Cont 4 (2): 149-153.
  • Gale RP, Büchner T, Zhang MJ, Heinecke A, Champlin RE, Dicke KA, Gluckman E, Good RA, Gratwohl A, Herzig HA, Keating A, Klein JP, Marmont AM, Prentice G, Rowlings PA, Sobocinski KA, Speck B, Weiner RS, Horowitz MM. (1996) HLA-identical sibling bone marrow transplants versus chemotherapy for acute myeloid leukemia in first remission. Leukemia 10(11): 1687-91.
  • Kao KJ, Noyes W, Weiner RS, Hudson S, Waldman-Slone A. (1997) Leukocyte Reduction and Ultraviolet B Irradiation of Platelets to Prevent Alloimmunization and Refractoriness to Platelet Transfusions. NEJM 337(26): 1861-1869.
  • Champlin RE, Passweg JR, Zhang MJ, Rowling PA, Pelz CJ, Atkinson KA, Barrett AJ, Cahn JY, Drobyski WR, Gale RP, Goldman JM, Gratwohl A, Gordon-Smith EC, Henslee-Downey PJ, Herzig RH, Klein JP, Marmont AM, O'Reilly RJ, Ringden O, Slavin S, Sobocinski KA, Speck B, Weiner RS, Horowitz MM. (2000) T cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings: advantage of T-cell antibodies with narrow specificities. Blood 95(12): 3996-4003.
  • Miller AM, Morrison D, Safah H, Cullins S, LaRussa V, Rink J, Weiner RS. (2000) Decreased Quality of Peripheral Blood Progenitors Collected after a Peripheral Blood Progenitor Transplant. J Hemat Stem Cell Res 9: 475-480.
  • Bennett CL, Stinson RJ, Vogel V, Robertson L, Leedy DL, O'Brien P, Hobbs J, Sutton T, Ruckdeschel T, Chrirkos T, Weiner RS, Ramsey M, Wicha M. (2000) Evaluating the financial impact of clinical trials in oncology: results from a pilot sutdy from the Association of American Cancer Institutes/Northwestern Univeristy clinical trials costs and charges project. J Clin Onc 18(15): 2805-2810.

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Jeffrey K. WickliffeJeffrey K. Wickliffe
Assistant Professor

 

 

Positions and Employment

  • 1995-1996 Teaching Assistant, Department of Wildlife and Fisheries Sciences, Texas A&M Univ.
  • 1996-1997 Graduate Assistant, Department of Wildlife and Fisheries Sciences, Texas A&M Univ.
  • 1997-1998 Research Technician II, Department of Poultry Science, University of Georgia
  • 1998-1999 Graduate Assistant, Department of Biology, Texas Tech University
  • 1999-2002 Research Associate, Department of Biology, Texas Tech University
  • 2002-2004 Postdoctoral Fellow, Dept. of Prev. Med. and Comm. Health, Univ. Texas Med Branch
  • 2004-2006 Instructor, Dept. of Prev. Med. and Comm. Health, Univ. Texas Med Branch
  • 2006-2008 Assistant Professor, Dept. of Prev. Med. and Comm. Health, Univ. Texas Med Branch
  • 2009-Present Assistant Professor, Dept. of Env. Health Sci., Tulane University SPH&TM

Selected Publications

  • Abdel-Rahman, S. Z., M. M. Ammenheuser, C. J. Omiecinski, J. K. Wickliffe, J. I. Rosenblatt, and J. B. Ward, Jr. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). Toxicological Sciences 2005. 85(1):624-631.
  • Hill, C. E., J. K. Wickliffe, K. J. Wolfe, C. J. Kinslow, M. S. Lopez, and S. Z. Abdel-Rahman. The L84F and the I143V polymorphisms in the O6-methylguanine-DNA-methyltransferase (MGMT) gene increase human sensitivity to the genotoxic effects of the tobacco-specific nitrosamine carcinogen NNK. Pharmacogenetics and Genomics 2005. 15(8):571-578.
  • Wickliffe, J. K., L. A. Galbert, M. M. Ammenheuser, S. M. Herring, J. Xie, O. E. Masters, R. S. Lloyd, and J. B. Ward. 3,4-epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice. Environmental and Molecular Mutagenesis 2006. 47(1):67-70.
  • Wickliffe, J. K., Y. V. Dunina-Barkovskaya, S. P. Gaschak, B. E. Rodgers, R. K. Chesser, M. Bondarkov, and R. J. Baker. Variation in mitochondrial DNA control region haplotypes in populations of the bank vole, Clethrionomys glareolus, living in the Chornobyl environment. Environmental Toxicology and Chemistry 2006. 25(2):503-508
  • Wickliffe, J. K., S. M. Herring, L. A. Galbert, L. M. Hallberg, M. M. Ammenheuser, O. E. Masters, J. Xie, E. C. Friedberg, R. S. Lloyd, and J. B. Ward, Jr. Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: insights from animal models examining human sensitivity to 1,3-butadiene. Chemico-Biological Interactions 2007. 166(1-3):226-231.
  • Meeks, H. N., J. K. Wickliffe, S. R. Hoofer, R. K. Chesser, B. E. Rodgers, R. J. Baker. Mitochondrial control region variation in bank voles (Clethrionomys glareolus) is not related to Chernobyl radiation exposure. Environmental Toxicology and Chemistry 2007. 26(2):361-369.
  • Wolfe, K. J., J. K. Wickliffe, C. E. Hill, M. M. Ammenheuser, and S. Z. Abdel-Rahman. Single nucleotide polymorphisms of the DNA repair gene XDP/ERCC2 alter mRNA expression. Pharmacogenetics and Genomics 2007. 17:897-905.
  • Hill, C. E., J. K. Wickliffe, A. T. Guerin, C. J. Kinslow, K. J. Wolfe, M. M. Ammenheuser, and S. Z. Abdel-Rahman. The L84F polymorphism in the O6-Methylguanine-DNA-Methylransferase (MGMT) gene increases the HPRT mutant frequency in lymphocytes of tobacco smokers. Pharmacogenetics and Genomics 2007. 17(9):743-753.
  • Goggin, M., R. Loeber, S. Park, V. Walker, J. Wickliffe, N. Tretyakova. HPLC-ESI+-MS/MS analysis of N7-Guanine-N7-Guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene. Chemical Research in Toxicology 2007. 20(5):839-847.
  • Kinslow C. J., R. A. El-Zein, C. E. Hill, J. K. Wickliffe, S. Z. Abdel-Rahman. Single nucleotide polymorphisms 5' upstream of the coding region of the NEIL2 gene influence gene transcription levels and alter levels of genetic damage. Genes, Chromosomes and Cancer 2008. 47(11):923-932.
  • Wickliffe J. K., M. M. Ammenheuser, P. J. Adler, S. Z. Abdel-Rahman, J. B. Ward Jr. Evaluation of frequencies of HPRT mutant lymphocytes in butadiene polymer workers in a southeast Texas facility. Environmental and Molecular Mutagenesis 2009. 50(2):82-87.

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Thomas E. Wiese Thomas E. Wiese, Ph.D.

Assistant Professor of Environmental Health Sciences, Tulane School of Public Health and Tropical Medicine
TCC Program Member
twiese@xula.edu
(504) 988-6376, (504) 988-6428 fax
1430 Tulane Ave., Box SL-29, New Orleans, LA 70112-2699
Homepage: http://www.ehs.tulane.edu/Faculty-Profiles/Wiese-Tom.html


Dr. Wiese received his B.S. in Biology from the University of Michigan, Flint in 1984. He carried out doctoral studies in Biochemistry on the ligand specificity of the estrogen receptor with Dr. Samuel Brooks at Wayne State University School of Medicine and obtained his Ph.D. in 1995. He was a postdoctoral fellow with Drs. William Kelce and Earl Gray at the University of North Carolina at Chapel Hill and the US EPA NHEERL, working on molecular mechanisms of endocrine disruption. In 1998 Dr. Wiese took a joint faculty position in the Environmental Health Sciences, Tulane School of Public Health and Tropical Medicine and the College of Pharmacy, Xavier University of Louisiana. This position involves active collaboration with the Environmental Endocrinology Laboratory at the Center for Bioenvironmental Research at Tulane and Xavier Universities. Dr. Wiese has published papers on the subjects of endocrine disruption, structure-activity relationships of hormone active chemicals and estrogen mediated effects on gene induction and proliferation in breast cancer cells. The primary theme of Dr. Wiese's research is molecular mechanisms involved in nuclear receptor mediated endocrine disruption. Projects underway include characterizations of gene and tissue specific effects, receptor specific effects and species specific effects of hormone active environmental chemicals. Cellular, biochemical, molecular biological and molecular modeling approaches are applied in the Wiese lab to studies of the estrogen, androgen and progestin activity of environmental contaminants.


Recent Publications:
  • Waller CL, Oprea TI, Chae K, Park H-K, Korach KS, Laws SC, Wiese TE, Kelce WR, Gray LE. (1996) Ligand-based identification of environmental estrogens. Chem Res Toxicol 9: 1240-1248.
  • Gray LE, Kelce WR, Wiese TE, et.al. (1997) Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reprod Toxicol 11(5): 719-750.
  • Wiese TE, Polin LA, Palomino E, Brooks SC. (1997) Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17: A 3D QSAR study. J Med Chem 40(22): 3659-3669.
  • Bolger R, Nestich S, Wiese TE, Ervin K, Checovich W. (1998) Rapid screening of environmental chemicals for estrogen receptor binding capacity. Environ Health Pers 106(9): 551-557.
  • Walker C, Ahmed SA, Brown T, Ho SM, Hodges L, Lucier G, Russo J, Weigel N, Wiese TE, Vandenbergh J. (1999) Species, interindividual, and tissue specificity in endocrine signaling. Environ Health Pers 107: 619-624.
  • Burow ME, Boue SM, Collins-Burrow BM, Melnik LI, Doung BN, Carter-Wientjes CH, Li S, Wiese TE, Cleveland TE, McLachlan JA. (2001) Phytochemical glyceollins, isolated from soy, mediate anti-hormone effects through estrogen receptor alpha and beta. J Clin Endo Metab 86(4): 1750-1758.

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Christopher Williams
 ChrisTopher Williams, Ph.D.

Research Assistant Professor of Structural and Cellular Biology
TCC Program Member
cwillia0@tulane.edu
504-988-1562, 504-988-1687(fax)
1430 Tulane Ave., SL49, New Orleans, LA 70112

Biographical Narrative:

After receiving a Bachelor of Science in Biology from Southern University at New Orleans, Dr. Williams pursued a doctoral degree in Pharmacology at Tulane University under the tutelage of Dr. Krishna Agrawal. His research interests focused on the effects of the HIV-Tat protein in hematopoietic dysfunction in HIV-AIDS. After matriculation in 2003, Dr. Williams joined the laboratory of Dr. Frank Jones at Tulane University. Here, his research foculsed on the novel role of the ERB4 tyrosine receptor kinase as a molecular chaperone and transcriptional co-activator for Stat5a and estrogen receptor in breast cancer. Due to Hurricane Katrina, Dr. Williams continued his postdoctoral training in the laboratory of Dr. Brian Rowan at Tulane University, where his work centered on the identification and characterization of novel estrogen receptro phosphorylation sites and their impact on anti-estrogen therapy in breast cancer. Dr. Williams joined the Department of Structural and Cellular Biology as a Research Assistant Professor in 2008. Currently, Dr. Williams' work focuses on the characterization of novel ERα phosphorylation in breast cancer, as well as the impact of the NR4A orphan nuclear receptors on chemotherapeutic efficacy in various models of breast cancer.

Recent Publications:

  • Williams, C. Smith, C, Rowan, B Novel Phosphorylation Sites in Estrogen Receptor α: Impact on Receptor-Dependent Gene Expression and Phosphorylation by Protein Kinase CK2 (Manuscript Submitted).
  • Williams C. Allison JG. Vidal GA. Burow ME. Beckman BS. Marrero L. Jones FE. (2004)The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone Journal of Cell Biology. 167(3):469-78.
  • Williams C, Clark D, Duplessis T, Jones FE. (2005) ErbB4 regulates STAT5a transcriptional activity by modulating phosphorylation of both serine and phosphotyrosine residues. Journal of Biological Chemistry. 280(25):24175-80.
  • Zhu Y, Sullivan L, Nair S, Williams C, Arvind P, Marrero L, Vadlamudi R, Jones FE. (2006) Coregulation of Estrogen Receptor by Estrogen-Inducible ERBB4/HER4 Establishes a Growth Promoting Autocrine Signaling Pathway in Breast Cancer. Cancer Research 66(16)7991-7998.
  • Williams C, Mondal D, Agrawal K. (2005) HIV-1 Tat protein enhances CREB co-activation by CBP and increases megakaryocytic commitment of K562 cells. Experimental Biology & Medicine 230 (11): 872-84.
  • Mondal D, Williams C, Agrawal K. (2005) HIV-1 Tat modulates expression of the HIV-1 co-receptors CXCR4 and CCR5 in K562 hematopoietic progenitor cells. Experimental Biology & Medicine 230 (9):631-44.

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William C. Wimley William C. Wimley, Ph.D.

Assistant Professor of Biochemistry
TCC Program Member
wwimley@tulane.edu
(504) 988-7076, (504) 988-2739 fax
1430 Tulane Ave., Box SL-43, New Orleans, LA 70112
Homepage on the Biochemistry website:
http://www.tulane.edu/~biochem/faculty/wimley.htm


Biographical Narrative:

Dr. Wimley received his B.S. in Biophysics from the University of Connecticut, Storrs in 1985 and his Ph.D. in Biochemistry from the University of Virginia, Charlottesville in 1990. His postdoctoral studies were carried out in the Department of Physiology and Biophysics at the University of California at Irvine where he studied the structure, folding and design of proteins in membranes with Dr. Stephen H. White. During his postdoctoral tenure, Dr. Wimley received a three-year NRSA grant from the National Institutes of Health. Dr. Wimley joined the Tulane faculty in 1998 as an Assistant Professor in the Department of Biochemistry at the Health Sciences Center. The primary theme of Dr. Wimley's research is the structure, folding and design of proteins in membranes. Much of his research utilizes peptide models of membrane proteins. His laboratory uses both traditional and combinatorial chemistry to design and engineer peptide models that assemble into membrane proteins or that interact with membrane proteins. One of the laboratory's current projects is the design of membrane-spanning peptide pores using combinatorial chemistry and high-throughput screening. Such molecules will be used in antibiotic drug design, in drug delivery and in biosensor engineering. Another project in the laboratory involves the use of combinatorial chemistry and high throughput screening to design peptides that specifically interact with receptors that are overexpressed in cancer, including G-protein coupled receptors and receptor tyrosine kinases. These molecules will be used to modulate receptor activities and to target the delivery of drugs and cytotoxic agents to specific cells. Finally, the laboratory is involved in genomic and proteomic analysis of genome databases. The goal of this work is to improve the recognition and identification of membrane proteins in genomes and to improve the prediction of their structure and function.


Recent Publications:
  • White SH, Wimley WC. (1999) Membrane Protein Folding And Stability: Physical Principles. Ann Rev Biophys Biomolec Struc 28: 319-65.
  • Wimley WC, White SH. (2000) Determining The Membrane Topology Of Peptides By Fluorescence Quenching. Biochem 39: 161-70.
  • Wimley WC, White SH. (2000) A Membrane-Spanning alpha-Helix Designed to Insert Spontaneously. Biochem 39: 4432-42.
  • Bishop CM, Walkenhorst WF Wimley WC. (2001) Folding of beta-sheets in Membranes: Specificity and Promiscuity in Peptide Model Systems. J Mol Biol 309: 75-88.
  • Rausch JM, Wimley WC. (2001) A High-throughput Screen for Identifying Transmembrane Pore-forming Peptides. Analyt Biochem 293: 258-63.

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Mary Jo Wright Mary Jo Wright, M.D.

Associate Professor of Surgery
TCC Associate Member
mjwright@tulane.edu
(504) 988-2317
1430 Tulane Ave., Box SL-22, New Orleans, LA 70112


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Xiaocheng Wu
Associate professor and Assistant Director of Louisiana Tumor Registry

Positions and Employment

  • 1987-1991Assistant Professor and Assistant Director, Dept. of Health Effects, Chinese Academy of Preventive Medicine in Beijing
  • 1991-1995 Visiting Instructor, Depts. of Pathology, LSUHSC
  • 1995-1998 Instructor, Depts. of Pathology, LSUHSC
  • 1998-1999 Instructor, Epidemiology Program of School of Public Health, LSUHSC
  • 1999-2006 Assistant Professor, Epidemiology Program of School of Public Health, LSUHSC
  • 2006-to date Associate Professor, Epidemiology Program of School of Public Health, LSUHSC

Selected Publications

  • Chen VW, Shiao YH, Wu XC, Scheer WD, Lehmann HP, Ruiz BA. Differences in prevalence of p53 accumulation in breast cancer between black and white patients. Breast Cancer Res and Treat 1993;2:177.
  • Chen VW, Wu XC, Andrews PA, Fontham ETH, Correa P. Advanced stage at diagnosis: an explanation for higher than expected cancer death rates in Louisiana. J La State Med Soc 1994;146:137-145.
  • Chen VW, Correa P, Kurman RJ, Wu XC, Eley JW, Austin D, Muss H, Hunter C, Redmond C, Sobhan M, Coates R, Reynolds P, Herman AA, Edward BK. Histology characteristics of breast carcinoma in blacks and whites. Cancer Epidemiol Biomarkers Prev 1994;3:1-9.
  • Shiao YH, Chen VW, Scheer WD, Wu XC, Correa P. Racial disparity in the association of p53 gene alternation with breast cancer survival. Cancer Res1995;55:1485-1490.
  • Shiao YH, Chen VW, Wu XC, Scheer WD, Lehmann HP, Malcom GT, Boudreau DA, Ruiz B, Correa P. Racial comparison of p53 alternation in breast cancer: difference in prognostic value. In vivo 1996;10: 169-174.
  • Shiao YH, Chen VW, Lehmann HP, Wu XC, Correa P. Patterns of DNA ploidy and S-phase fraction associated with breast cancer survival in blacks and whites. Clin Cancer Res 1997;3:587-592.
  • Chen VW, Fenoglio-Preiser CM, Wu XC, Coates RJ, Reynolds P, Wickerham DL, Adrews P, Hunter C, Stemmerman G, Jackson JS, Edward BK, and the BWCSS Group. Aggressiveness of colon carcinoma in blacks and whites. Cancer Epidemiol Biomarkers Prev 1997;6:1087-1983.
  • Chen VW, Wu XC, Andrews PA, Correa CN, Lucas HF. Highlights of cancer incidence in Louisiana, 1988-92. J La State Med Soc 1997;149;119-124.
  • Chen VW, Andrews PA, Wu XC, Correa CN, Fontham ETH. Cancer incidence in the industrial corridor: an update. J La Med Soc 1998;150:158-167.
  • Chen VW, Wu XC, Ahmed MN, Correa C, Andrews P. Cancer of the Colon and Rectum in Louisiana. J La Med Soc 1999;51:189-197.
  • Chen VW, Correa C, Andrews P, Wu. XC, et al. Louisiana Tumor Registry: New Developments and Activities. J La Med Soc 1999;51:214-217.
  • Ahmed M, Andrews P, VW Chen, Wu XC, et al. Incidence, Trends, and Mortality Rate of Prostate Cancer in Louisiana. J La Med Soc 2000;152;195-203.
  • Ahmed MN, Andrews PA, Wu XC, Schimdt BA, Correa CN, Chen VW. Occupation and industry information in death certificates and state-wide cancer registry database. J Registry Management 2000;27(4):132-135.
  • Wu XC, Correa C, Andrews P, Schmidt B, Ahmed M, Chen VW, Fontham E. Stage of disease at diagnosis and survival estimates for cancer of the colon and rectum in Louisiana. J La Med Soc 2000;152:171-180.
  • Huebner W, Chen VW, Wu XC, et al. Incidence of lymphohematopoietic malignancies in a petrochemical industry Cohort: 1983-94 follow-up. Occup Environ Med 2000;57:605-614.
  • Wingo PA, Luke El., O'Brien K, Brogan DJ, Chen VW, Wu XC, et al. Population-based patterns of care studies: Collaboration among State Cancer Registries, The American College of Surgeons, and The American Cancer Society. J Registry Management 2001; 28:5-16.
  • Wu XC, Andrews PA, Correa CN, et al. Breast cancer: incidence, mortality, and early detection in Louisiana, 1988-1997. J La Med Soc 2001;153:198-209.
  • Wu XC, Chen VW, Steele B, et al. Subsite-specific incidence rate and stage of disease in colorectal cancer by race, gender and age group in the United States, 1992-1997. Cancer 2001;92;2547-54.
  • Chen VW, Schmidt BA, Wu XC, Correa CN, et al. Childhood cancer in Louisiana, 1988-1996. J La Med Soc 2002;154:91-99.
  • MacLennan PA, Delzall E, Sathiakumar N, Myers SL, Cheng H, Grizzle W, Chen VW, Wu XC. Cancer incidence among triazine herbicide manufacturing workers. J Occup Environ Med 2002;44:1048-58.
  • Goodman MT, Correa CN, Tung KH, Roffers SD, Wu XC, Young JL, Wilkens LR, Carney ME, Howe HL. Stage disease of ovarian cancer in the United States, 1992-1997. Cancer 2003;97:2648-2659.
  • Chen VW, Ruiz B, Killeen JL, Cote TR, Wu XC, Correa CN. Pathology and classification. Cancer 2003;97:2631-2642.
  • Roffers SD, Wu XC, Johson CH, Correa CN. Incidence of extraovarian primary cancers in the United States, 1992-1997. Cancer 2003;97(10):2643-2647.
  • Young JL, Wu XC, Roffers SD, Howe HL, Correa CN, Weinstein R. Ovarian cancer in children and young adults in the United States, 1992-1997. Cancer 2003;97:2694-2700.
  • Wu XC, Chen VW, Ruiz B, Andrew PA, Hsieh MC, et al. Patterns of treatment for ducatal carcinoma in situ of the breast in Louisiana, 1988-1999. J La Med Soc 2003;155:206-213.
  • Wu XC, Chen VW, Steele B, Roffers S, Klotz JB, Correa CN. Cancer incidence in adolescents and young adults in the United States, 1992-1997. J Adolesc Health 2003;32:405-415.
  • Tsai SP, Chen VW, Fox EE, Wendt JK, Wu XC, et al. Cancer Incidence among Refinery and Petrochemical Employees in Louisiana, 1983-1999. Ann Epidemiol 2004:14:722-730.
  • Jemal A, Clegg LX, Ward E, Ries LAG, Wu XC, Jamison PM, Wingo PA, Howe PA, Anderson RN, Edwards BK. Annual report to the nation on the status of cancer, 1975-2001, with a special feature on survival. Cancer 2004;101(1):1-25.
  • Wu XC, Chen VW, Andrews PA, et al. Treatment Patterns for Stage III Colon Cancer and Factors Related to Receipt of Postoperative Chemotherapy in Louisiana. J La Med Soc 2004;156;255-261.
  • Wu XC, Chen VW, Martin HJ, et al. Subsite Specific Colorectal Cancer Incidence Rates and Stage Distributions among Asians/Pacific Islanders in the United States, 1995-1999. Cancer Epidemiol Biomarkers Prev 2004;13:1-8.
  • Jemal A, Clegg LX, Ward E, Ries LAG, Wu XC, Jamison PM, Wingo PA, Howe PA, Anderson RN, Edwards BK. Annual report to the nation on the status of cancer, 1975-2001, with a special feature on survival. Cancer 2004;101:3-27.
  • Adelman AS, McLaughlin, Wu XC, Chen VW, Goves FD. Urbanization and incidence of acute lymphocytic leukemia among United States children ages 0-4. Br J Cancer 2005;92:2084-2088. Jun 6.
  • McLaughlin CC, Wu XC, Jemal A, Martin HJ, Roche LM, Chen VW. Incidence of noncutaneous melanomas in the U.S. Cancer 2005;103:1000-7. Mar 1, 2005
  • Wu XC, Groves FD, McLaughlin CC, Jemal A, Martin HJ, Chen VW. Cancer incidence patterns among adolescents and young adults in selected U.S. areas. Cancer Causes Control 2005;16(3):309-320. Apr 2005
  • Wu XC, Chen VW, Andrews PA, Chen LS, Hsieh MC, Ahmed MN, Fontham ETH. Initial treatment patterns for clinically localized prostate cancer and factors associated with the treatment in Louisiana. J La Med Soc 2005;157;188-194. Jul-Aug 2005
  • Edward BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LAG, Schrag D, Jamison PM, Jenal A, Wu XC, Frieman C, Harlan L, Warren J, Anderson RN, Pickle LW. Annual Report to the Nation on the Status of Cancer, 1975-2002, Featuring Population-Based Trends in Cancer Treatment. J Natl Cancer Inst2005;5;97:1407-27. Oct 5, 2005
  • Wu XC, Chen VW, Ruiz B, Andrews PA, Su JL, Correa P. Incidence of esophageal and gastric cancers among American Asians/Pacific Islanders, Whites, and Blacks, Subsites and Histology Difference. Cancer 2006;106:683-92. Feb 1.
  • Mather F, Chen VW, Morgan LH, Correa CN, Shaffer JG, Srivastav SK, Rice JC, Blount G, Swalm CM, Wu XC, Scribner RA. Hierarchical modeling and other spatial analysis in prostate cancer incidence data. Am J Prev Med 30 (2S):S88-S100, Feb, 2006.
  • Ahmed F, Goodman MT, Kosary C, Ruiz B, Wu XC, Chen VW, Correa CN. Excess risk of subsequent primary cancers among colorectal carcinoma survivors, 1975-2001. Cancer 107 (5 suppl): 1162-71. Sept 1, 2006.
  • Wu XC, Cokkinides V, Chen WV, Nadel M, Ren Y, Martin J, Ellison GL. Association of Subsite-specific Colorectal Cancer Incidence Rates and Stage at Diagnosis with County Poverty Levels, by Race and Sex, 1998-2001. Cancer 107(5 suppl):1121-7. Sept 1, 2006.
  • Howe HL, Wu XC, Edwards BK, Ahmed F, Jemal A, Cokkinides V, Ries AG, Williams M, Ward E, Wingo PA, Miller B, Ramirez A. Annual Report to the Nation on the Status of Cancer, 1975-2003, Featuring Cancer among U.S. Hispanic/Latino Populations. Cancer 2006;107:1711-42. Oct 15, 2006.
  • Wu XC, Chen VW, Andrews PA, Ruiz B, Correa P. Incidence of esophageal and gastric cancers among Hispanics, non-Hispanic whites, and non-Hispanic blacks in the United States: subsite and histology differences. Cancer Causes Control 2007;18:585-593. Aug 2007.
  • Joseph D, Wingo P, King J, Pollack L, Richardson L, Chen VW, Wu XC, Rogers D, Cook J. Use of State Cancer Surveillance Data to Estimate the Cancer Burden in Disaster-Affected Areas: Hurricane Katrina, 2005.Prehospital and Disaster Medicine.2007; 22(4):282-90. Jul-Aug 2007.
  • Espey DK, Wu XC, Swan J, Wiggins C, Jim M, Ward E, Wingo PA, Howe HL, Ries LAG, Miller BA, Jemal A, Ahmed F, Cobb N, Kaur JS, Edwards BK. Annual Report to the Nation on the Status of Cancer, 1975-2004, Featuring Cancer in American Indians and Alaska Natives. Cancer 2007;110(10):2119-52. Nov 2007.
  • Wu XC, Richardson LC, Kahn AR, Fulton JP, Cress RD, Shen TF, Wolf HJ, Bolick-Aldrich S, Chen VW. Survival Difference between Non-Hispanic Black and Non-Hispanic White Women with Localized Breast Cancer: The Impact of Guideline-Concordant Therapy in the U.S. J Natl Med Assoc 2008;100(5):490-498. May 2008.
  • Wu XC, Matanoski G, Chen VW, Saraiya M, Coughlin C, King J, Tao XC. Descriptive Epidemiology of Vaginal Cancer Incidence and Survival by Race, Ethnicity, and Age in the United States. Cancer 113 (10 Suppl.): 2873-2882, Nov 2008.
  • Joseph DA, Miller JW, Wu XC, Chen VW, Morris CR, Goodman MT, Villalon-Gomez JM, Williams MA, Cress RD. Understanding the burden of HPV-associated anal cancers in the United States. Cancer 2008;223 (10 suppl): 2892-9000. Nov 2008.
  • Saraiya M, Watson M, Wu XC, King J, Chen VW, Smith JS, Giuliano AR. Incidence of In Situ and Invasive Vulvar Cancer in the United States, 1998-2003. Cancer113 (10 Suppl.): 2865-2872, Nov 2008.
  • Ryerson AB, Peters ES, Coughlin SS, Chen VW, Gillison ML, Reichman ME, Wu XC, Chaturvedi AK, Kawaoka K. Burden of Potentially HPV-Associated Cancer of the Oropharynx and Oral Cavity in the United States, 1998-2003. Cancer 113 (Suppl. 10): 2901-2909, Nov 2008.
  • Jemal A, Thun MJ, Ries, LAG, Howe H, Weir HK, Center MM, Ward, E, Wu, XC, Eheman C, Anderson R, Ajani UA, Kohler B, Edwards, BK. Annual report to the nation on the status of cancer, 1975-2005, feasuring trends in lung cancer, tobacco use, and tobacco control. J Natl Cancer Inst 2008; 100:1-23. Nov, 2008.

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Guangyu Wu, Ph.D.
Associate Professor, Department of Pharmacology
Louisiana State University Health Sciences Center
gwu@lsuhsc.edu
(504) 568-2236
1901 Perdido Street, MEB P7-1, New Orleans, LA, 70112

 

Biographical Narrative:
Guangyu Wu, PhD, is an Associate Professor in the Department of Pharmacology. His research interests include export trafficking and signal regulation of G protein-coupled receptors (GPRCs). These receptors constitute the largest family of cell-surface proteins that modulate cell functions such as proliferation, survival, and motility. Recent studies have shown that GPCRs play an important role in the initiation and progression of multiple cancers. More interestingly, GPCRs may be used for the early diagnosis of cancers.  Dr. Wu's studies may provide a foundation for the development of new drugs for prevention and treatment of cancers.

Positions and Employment

  • 1983 – 1988 Teaching Assistant, Department of Biochemistry, Xuzhou Medical College, Xuxhou, China

  • 1988 – 1993 Assistant Professor, Department of Physiology, Peking Union Medical College, Beijing, China

  • 1993 – 1994 Associate Professor, Department of Physiology, Peking Union Medical College, Beijing, China

  • 1995 – 1998 Postdoctoral Fellow, Department of Pharmacology, Medical University of South Carolina, Charleston, SC

  • 1999 – 2001 Assistant Professor Research, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH

  • 2001 – 2006 Assistant Professor, Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA

  • 2003 – present Member, Center of Excellence for Cardiovascular Research,, Louisiana State University Health Sciences Center, New Orleans, LA.

  • 2006 – present Associate Professor, Department of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA

Selected Publications

  • Wu G, Krupnick JG, Benovic JL and Lanier SM. Interaction of arrestins with intracellular domains of muscarinic and a2-adrenergic receptor. J Biol Chem 272:17836-17842 (1997).

  • Wu G, Benovic JL, Hildebrandt JD and Lanier SM. Receptor docking sites for G-protein bg subunits: Implications for signal regulation. J Biol Chem 273:7197-7200 (1998) (Accelerated Communication).

  • Dorn GW II, Souroujon MC, Liron T, Chen CH, Gray MO, Zhou HZ, Csukai M, Wu G, Lorenz JN and Mochly-Rosen D. Sustained in vivo cardiac protection by a rationally designed peptide that causes e protein kinase C translocation. Proc Natl Acad Sci USA 96:12798-12803 (1999).

  • Wu G, Toyokawa T, Hahn H and Dorn GW II. e Protein kinase C in pathological myocardial hypertrophy: Analysis by combined transgenic expression of translocation modifiers and Gq. J Biol Chem 275:29927-29930 (2000) (Accelerated Communication).

  • Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Robbins J and Dorn GW II. Cardiotrophic effects of e protein kinase C: analysis by in vivo modulation of PKC translocation. Circ Res 86:1173-1179 (2000).

  • Dorn GW II, Tepe NM, Wu G, Yatani A and Liggett SB. Mechanisms of impaired b-adrenergic receptor signaling in Gaq-mediated cardiac hypertrophy and ventricular dysfunction. Mol Pharmacol 57:278-287 (2000).

  • Wu G, Bogatkevich, GS, Mukhin YV, Benovic JL, Hildebrandt JD and Lanier SM. Identification of Gbg-binding sites in the third intracellular loop of the muscarinic receptors and their role in receptor regulation. J Biol Chem 275:9026-9034 (2000).

  • Wu G, Yussman MG, Barrett T, Hahn H, Osinska H, Hilliard GM, Wang X, Toyokawa T, Yatani A, Lynch RA, Robbins J and Dorn GW II. Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy. Circ Res 89:1130-1137 (2001).

  • Chen L, Hahn H, Wu G, Chen CH, Liron T, Schechtman D, Cavalo G, Banci L, Bolli R, Dorn GW and Mochly-Rosen D. Opposing cardioprotective actions and parallel hypertrophic effects of dPKC and ePKC. Proc Natl Acad Sci USA 98:11114-11119 (2001).

  • Sato Y, Kiriazis H, Yatani A, Schmidt AG, Hahn H, Ferguson DG, Sako H, Mitarai S, Honda R, Mesnard-Roullier L, Frank KF, Beyermann B, Wu G, Fujimori K, Dorn GW II, and Kranias EG. Rescue of contractile parameters and myocyte hypertrophy in calsequestin-overexpressing myocardium by phospholamban ablation. J Biol Chem 296:9392-9399 (2001).

  • Yussman MG, Toyokawa T, Odley A, Lynch R, Wu G, Colbert MC, Aronow BJ, Lorenz JN, Dorn GW II. Mitochondrial dealth protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nature Medicine 8(7):725-730 (2002). 

  • Wu G, Bernard ML and Lanier SM. Protein interaction assays with G-proteins. Methods Enzymol 344:521-535 (2002).

  • Wu G*, Zhao G, He Y. Distinct pathways for the trafficking of angiotensin II and adrenergic receptors from the endoplasmic reticulum to the cell surface: Rab1-independent transport of a G protein-coupled receptor. J Biol Chem  278:47062-47069 (2003) (*Corresponding author)

  • Duvernay MT, Zhou F and Wu G. A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface. J Biol Chem 279(29):30741-30750 (2004).

  • Filipeanu CM, Zhou F, Claycomb WC and Wu G. Regulation of the cell-surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes. J Biol Chem 279(39):41077-41084 (2004).

  • Duvernay MT, Filipeanu CM, and Wu G. The regulatory mechanisms of export trafficking of G protein-coupled receptors. Cell Signal 17:1457-1465 (2005) (Invited review).

  • Zhou F, Filipeanu CM, Duvernay MT and Wu G. Cell-surface targeting of a2-adrenergic receptors - Inhibition by a transport deficient mutant through dimerization. Cell Signal 18:318-327 (2006).

  • Dong C and Wu G. Regulation of anterograde transport of 2-adrenergic receptors by the N-termini at multiple intracellular compartments. J Biol Chem 281:38543-38554 (2006).

  • Filipeanu CM, Zhou F, Lam ML, Kerut KE, Claycomb WC and Wu G. Enhancement of recycling and signaling of b-adrenergic receptors by Rab4 in cardiac myocytes. J Biol Chem 281:11097-11103 (2006).

  • Filipeanu CM, Zhou F, Fugetta EK and Wu G. Differential regulation of the cell-surface targeting and function of b- and a1-adrenergic receptors by Rab1 GTPase in cardiac myocytes. Mol Pharmacol 69:1571-1578 (2006).

  • Dong C and Wu G. Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. Cell Signal 19:2388-2399 (2007).

  • Dong C, Filipeanu CM, Duvernay MT and Wu G. Regulation of G protein-coupled receptor export trafficking. Biochim Biophys Acta 1768:853-870 (2007) (Invited review).  

  • Dong C, Zhou F, Fugetta EK, Filipeanu CM and Wu G. Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase. Cell Signal 20:1035-1043 (2008).

  • Wang G, Qian G, Jackson FR,  Qian P and Wu G. Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells. Int J Biochem Cell Biol 40:461-470 (2008).

  • Feng Y, Yue X, Xia H, Bindon SM, Filipeanu CM, Wu G and Lazartigues E. ACE2 over-expression in the subfornical organ is associated with down-regulation of the AT1 receptor and prevention of angiotensin-II-mediated pressor and drinking responses. Circ Res 102:729-736 (2008).

  • Filipeanu CM, Zhou F and Wu G. Analysis of Rab1 function in cardiomyocyte growth. Methods Enzymol 438:217-226 (2008).

  • Wu G. Regulation of the trafficking and function of G protein-coupled receptors by Rab1 GTPase in cardiomyocytes. Methods Enzymol 438:227-238 (2008).

  • Duvernay MT, Dong C, Zhang X, Robitaille M, Hébert TE and Wu G. A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors. Traffic 10: 552-566 (2009).

  • Duvernay MT, Dong C, Zhang X, Zhou F, Nichols CD and Wu G. Anterograde trafficking of G protein-coupled receptors: function of the F(x)6LL motif in export from the endoplasmic reticulum. Mol Pharmacol 75:751-761 (2009).

  • Zhang X, Wang G, Dupré DJ, Feng Y, Lazartigues E, Feng YH, Hébert TE and Wu G. Roles of Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. JPET 330: 109-117 (2009).

  • Huang W, Wu G and Wang G. Cell type-specific and light-dependent expressions of Rab1 and Rab6 GTPases in mammalian retinas. Visual Neuroscience 26: 443-452 (2010).

  • Dong C, Zhang X, Zhou F, Dou H, Duvernay MT, Zhang P and Wu G. ADP-ribosylation factors modulate the cell surface transport of G protein-coupled receptors. JPET (in presss) (2010).

  • Dong C, Yang L, Zhang X, Lam ML, Claycomb WC and Wu G. Rab8 interacts with distinct motifs in a2B- and b2-adrenergic receptors and differentially modulates their transport. J Biol Chem (in revision).

  • Zhang Z, Wang G, Wang Y, DeCoster MA, Bai L, Ma Z, Qian G and Wu G. Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia (submitted).



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