A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Vedeckis

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Wayne V. Vedeckis, Ph.D.
Amgen Professor of Oncology

 

 

Positions and Employment

• 1979 – 1984 Assistant Professor, Department of Biochemistry, Louisiana State University Medical Center, New Orleans, Louisiana
• 1984 – 1988 Associate Professor, Department of Biochemistry and Molecular Biology, Louisiana State
  University Medical Center, New Orleans, Louisiana
• 1986 – 1987 Sabbatical Leave with Dr. Jonathan Karn, Laboratory of Molecular Biology, Medical Research Council, Cambridge, England
• 1988 – 1992 Professor (20% effort), Gene Expression Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana
• 1988 – present Professor, Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans, Louisiana
• 1994 – 1996 Assistant Director for Basic Sciences, LSUMC Stanley S. Scott Cancer Center, New Orleans, Louisiana
• 1997 – 2006 Associate Director for Basic Sciences, LSUMC Stanley S. Scott Cancer Center, New Orleans, Louisiana
• 2001 – 2004 Acting Head, Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana
• 2006 – present Co-leader, Molecular Signaling Program, LSUMC Stanley S. Scott Cancer Center and Louisiana Cancer Research Consortium, New Orleans, Louisiana
• 2008 – present Interim Head, Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, Louisiana

Selected Publications:

• Vig, E., Barrett, T. J. and Vedeckis, W.V. (1994). Coordinate regulation of glucocorticoid receptor and c-jun mRNA levels: evidence for cross-talk between two signaling pathways at the transcriptional level. Mol. Endocrinol. 8, 1336-1346.
• Barrett, T.J., Vig, E. and Vedeckis, W.V. (1996). Coordinate regulation of glucocorticoid receptor and c-jun gene expression is cell-type specific and exhibits differential hormonal sensitivity for down- and up-regulation. Biochemistry 35, 9746-9753.
• Breslin, M.B. and Vedeckis, W.V. (1996). The glucocorticoid receptor and c-jun promoters contain AP-1 sites that bind different AP-1 transcription factors. Endocrine 5, 15-22.
• Barrett, T.J. and Vedeckis, W.V. (1996). Occupancy and composition of proteins bound to the AP-1 sites in the glucocorticoid receptor and c-jun promoters after glucocorticoid-treatment and in different cell types. Receptors & Signal Transduction 6, 179-193.
• Wei, P. and Vedeckis, W.V. (1997). Regulation of the glucocorticoid receptor gene by the AP-1 transcription factor. Endocrine 7, 303-310.
• Wei, P., Ahn, Y.I., Housley, P.R., Alam, J. and Vedeckis, W.V. (1998). Modulation of hormone- dependent glucocorticoid receptor function using a tetracycline-regulated expression system. J. Steroid Biochem. Mol. Biol. 64, 1-12.
• Wei, P., Inamdar, N. and Vedeckis, W.V. (1998). Transrepression of c-jun gene expression by the glucocorticoid receptor requires both AP-1 sites in the c-jun promoter. Mol. Endocrinol. 12, 1322-1333.
• Breslin, M.B. and Vedeckis, W.V. (1998). The human glucocorticoid receptor promoter upstream sequences contain binding sites for the ubiquitous transcription factor, Yin Yang 1. J. Steroid Biochem. Mol. Biol. 67, 369-381.
• Wagner, B.L., Pollio, G., Giangrande, P., Webster, J.C., Breslin, M., Mais, D.E., Cook, C.E., Vedeckis, W.V., Cidlowski, J.A. and McDonnell, D.P. (1999). The novel progesterone receptor antagonists RTI 3021-012 and RTI 3021-022 exhibit complex glucocorticoid receptor antagonist activities: implications for the development of dissociated antiprogestins. Endocrinology 140, 1449-1458.
• Oliver, P.D., Vedeckis, W., Brimmer, S., Watson, B. and Gardner, R.V. (1999). Apoptosis among normal bone marrow and hematopoietic stem cells after exposure to chemotherapeutic agents. Cancer Res. Ther. Control 10, 81-92.
• Nunez, B.S. and Vedeckis, W.V. (2001). Monitoring nuclear receptor function. In Receptors: Structure and Function: A Practical Approach, 2nd Ed., (C. Stanford and R. Horton, Eds.). Oxford University Press, Oxford, England, pp. 233-256.
• Breslin, M.B., Geng, C.-d. and Vedeckis, W.V. (2001). Multiple promoters exist in the human glucocorticoid receptor gene, one of which is activated by glucocorticoids. Mol. Endocrinol. 15, 1381-1395.
• Nunez, B.S. and Vedeckis, W.V. (2002) Characterization of promoter 1B in the human glucocorticoid receptor gene. Mol. Cell. Endocrinol. 189, 191-199.
• Pedersen, K.B. and Vedeckis, W.V. (2003). Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 42, 10978-10990.
• Geng, C.-D. and Vedeckis, W.V. (2004). Steroid-responsive sequences in the human glucocorticoid receptor gene 1A promoter. Mol. Endocrinol. 18, 912-924.
• Pedersen, K.B., Geng, C.-d. and Vedeckis, W.V. (2004). Three mechanisms are involved in glucocorticoid receptor autoregulation in a human T-lymphoblast cell line. Biochemistry 43, 10851-10858.
• Nunez, B.S., Geng, C.-d., Pedersen, K.B., Millro-Macklin, C.D. and Vedeckis, W.V. (2005). Interaction between the interferon cell signaling pathway and the human glucocorticoid receptor gene 1A promoter. Endocrinology 146, 1449-1457.
• Geng, C.-d., Pedersen, K.B., Nunez, B.S. and Vedeckis, W.V. (2005). Human glucocorticoid receptor α transcript splice variants with exon 2 deletions: evidence for tissue- and cell type specific functions. Biochemistry 44, 7395-7405.
• Geng, C.-d. and Vedeckis, W.V. (2005) c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter, J. Biol. Chem. 280, 43264-43271.
• Geng, C.-d., Schwartz, J.R and Vedeckis, W.V. (2008). A conserved molecular mechanism is responsible for the auto-upregulation of glucocorticoid receptor gene promoters. Mol. Endocrinol., (revised version under review).
  

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