M Raj, Ramayya, Roberts, Rose, Rowan
Madhwa H.G. Raj
Professor of Ob-Gyn, Biochemistry & Molecular Biology.
Positions and Employment:
- 1969: WHO sponsored training program on Molecular aspects of antigenicity and immunoglobulins. Weizman Institute of Science, Rehovot, Israel.
- 1968-1971: Research Officer, Dept. of Biochemistry, Indian Institute of Science, Bangalore, India.
- 1971-1974: Post-doctoral Research Fellow (Prof. Roy O. Greep, Mentor). Lab of Human Reprod. & Reprod. Biol., Harvard Medical School, Boston.
- 1974-1976: Research Associate, Dept. of Physiology and Lab. of Human Reprod & Reprod. Biol, Harvard Medical School, Boston.
- 1976-1982: Assistant Professor, Depts of Ob-Gyn and Pharmacology, Univ. N. Carolina School of Medicine, Chapel Hill., N. Carolina
- 1982-1984: Associate Professor, Depts of Ob-Gyn and Pharmacology, Univ. N. Carolina School of Medicine, Chapel Hill, N.Carolina
- 1984-Present: Professor / Director of Research Laboratories, Dept. of Ob-Gyn and Biochemistry, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, LA.
Positions and Employment:
- Madhwa Raj HG , Moudgal NR. Hormonal control of gestation in the intact rat Endocrinology 1970, 86:874-889.
- Madhwa Raj HG, Moudgal NR. Effect of neutralizing luteinizing hormone activity on the ovulation process in the rat. Nature 1970, 227:1344-1345.
- Madhwa Raj HG, Greep RO. Inhibition of ovulation and LH secretion in the cyclic rat by ergotamine tartrate. Proc. Soc. Exp. Biol. Med. 1973, 144:960-962.
- Madhwa Raj HG, Macdonald GJ, Greep RO. Involvement of luteinizing hormone as a luteotropin in the Golden Hamster. Proc. Soc. Exp. Biol. Med. 1974, 145:196-199.
- Madhwa Raj HG. “Antigonadotropins and the endocrine function of the ovary” in: Edwards RG, Johnson MH (eds): Physiological Effects of Immunity Against Hormones. Cambridge University Press, London. 1975. pp.187-204.
- Madhwa Raj HG, Dym M. Effects of selective withdrawal of FSH or LH on spermatogenesis in the immature rat. Biol. Reprod. 1976, 14:489-494.
- Dym M, Madhwa Raj HG. Response of adult rat Sertoli cells and Leydig cells to depletion of luteinizing hormone and testosterone. Biol. Reprod. 1977, 17:676-696.
- Moudgal NR, Muralidhar K, Madhwa Raj HG. “Pituitary Gonadotropins” in Jaffe RB, Behrman HR (eds). Methods of hormone radioimmunoassay. Academic Press, New York 1979. pp.173-194.
- Halme JK, Becker S, Hammond MG, Madhwa Raj HG, Raj SG. Increased activation of pelvic macrophages in infertile women with mild endometriosis. Am. J. Obstet. Gynecol. 1983 145:333-337.
- Groff T, Madhwa Raj HG, Talbert LM, Willis D. Effects of neutralization of luteinizing hormone on corpus luteum function and cyclicity in Macaca fasicularis. J. Clin. Endocrinol. Metab. 1984, 59:1054-1057.
- Talbert M, Madhwa Raj HG, Hammond MG, Greer T. Endocrine and immunologic studies in a patient with resistant ovary syndrome. Fertil. Steril. 1984, 42:741-746.
- Zhang X, Baliga R, Reddy LR Madhwa Raj H G. Antibody against synthetic rat PTH peptide (1-34) blocks PTH mediated signal transduction and regulation of sodium dependent phosphate transport in OK cells, l997, Nephron. 75:245-248.
- Prasad GL, Masuelli L, Madhwa Raj HG, Harindranath N. Suppression Src induced transformed phenotype by expression of Tropomyosin-1. Oncogene 1999, 18:2027-2031.
- Rao PN, Levine E, Myers MO, Prakash V, Watson J, Stolier A, Kopicko J, Kissinger P, Raj SG and Madhwa Raj HG. Elevation of serum riboflavin carrier protein (RCP) in breast cancer. Cancer Epidemiology, Biomarkers and Prevention 8:985-990, 1999.
- Rao PN, Levine E, Prakash V, Myers M, Kopicko J, Madhwa Raj HG. Comparison of serum C-erbB-2 and riboflavin carrier protein levels as detection markers for breast cancer. Proc. Amer. Assoc. Cancer. Res. 42, 40, 2001, Abstract number 56.
- Madhwa Raj HG, Su LJ, Raj SG, Nataraj D, Skinner J, Braley P, Graham M, Espinosa T and Rao PN. Evaluation of riboflavin carrier protein (RCP) as a serum and tumor marker of ovarian epithelial cancer. Proc. Amer. Assoc. Cancer. Res. 2001, 42:41, Abstract number 242.
- Rao PN, Crippin J, Prakash V, Kopicko J, Levine E and Madhwa Raj HG. Elevation of serum RCP levels in primary hepatocellular carcinoma (HCC). Hepatol. Res. 2006. 35:83-87
- Tanya Roy, S. Parulekar, D Nataraj, JB Heneghen, O Sartor, PN Rao and Madhwa HG Raj. Role of vitamin binding proteins in prostate cancer. Proc. Amer. Assoc. Cancer Res. 2003, 44:1242, Abstract number 5418.
- PN Rao, DL Dyess, J Su, Madhwa Raj and B Trock. Serum and nipple aspirate fluid levels of riboflavin carrier protein in breast cancer. Proc. Amer. Assoc. Cancer Res. 2003, 44:1352, (abstract # 5894)
- Madhwa Raj HG, Tanya Roy, A Karande, PN Rao, K Richardson, SG Raj. Expression patterns riboflavin carrier protein (RCP) in the female reproductive system. Proceedings of the 59th annual meeting of the American Society for Reproductive Medicine, Fertility and Sterility: Abstracts of the Scientific Oral and Poster Sessions Program Supplement, September 2003, 80 (Suppl.3) S249-S250.
- Ouhtit A, Abd Elmageed ZY, Abdraboh ME, Lioe TF, Madhwa Raj HG. In vivo evidence for the role
of CD44s in promoting breast cancer metastasis to the liver. Am. J Pathol. Am.J. Pathol.,2007, 171: 2033-2039 - Deo, D.D., Rao, A.P., Bose, S.S., Ouhtit, A., Baliga, S.B., Rao, S.A., Trock, B.J., Thouta, R., Madhwa Raj H.G, Rao, P.N. Differential effects of leptin on the invasive potential of androgen dependent and independent prostate carcinoma cells. Journal of Biomedicine and Biotechnology 2008;2008:163902. PMID:18584049 [PubMed-indexed for MEDLINE].
- Madhwa Raj H.G., Abd-Elmageed, Z.Y., Zhou. J., Gaur, R.L., Nguyen, L.N., Azam G.A., Rao, P.N. and Ouhtit., A. Synergistic action of dietary phyto-antioxidants on survival and proliferation of ovarian cancer cells. Gynecologic Oncology, 2008, 110:432-438.
- Zakaria Y Abd Elmageed, Mandy Williams and Rajiv Gaur, Madhwa HG Raj, Ouhtit A. Independent coordination of the immediate responses by p16INK4A and p53 pathways in UVB-irradiated human skin. Journal of Investigative Dermatology advance online publication. J Invest Dermatol. 2009;129: 175-83
- Ouhtit A, Gaur RL, Abd Elmageed ZY, Fernando A, Thouta R, Trappey AK, Mohamed E Abdraboh, El-Sayyad HI, Rao PN, Raj MGH. Towards understanding the mode of action of the multifaceted cell adhesion receptor CD146. BBA Cancer Reviews (http://dx.doi.org/10.1016/j.bbcan.2009.01.002)
- Johnson T, Ouhtit A, Abd-Elmageed ZY, Schwarzenberger P, Su JL, Sartor O, Karande A, Rao PN, Raj MHG. Riboflavin carrier protein (RCP) is a tumor marker of prostate cancer. Front Biosc 2009; 14: 3634-3640 (http://www.bioscience.org/2009/v14/af/4077/3.htm)
- Hassan HA, El-Agmy SM, Gaur RL, Fernando A, Raj MH, Ouhtit A. In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress. Int J Biol Sci. 2009; 5: 249-55
- Trappey AK, Fernando A, Gaur R, Raj MHG, Ouhtit A. The shady side of sunlight: current understanding of the mechanisms underlying UV-induction of skin cancers. Front Biosc (In Press)
Assistant Professor of Pediatrics, Section of Endocrinology
TCC Contributing Member
mramayya@tulane.edu
1430 Tulane Ave., Box SL-37, New Orleans, LA 70112-2699
(504) 988-5456
Biographical Narrative:
Dr. Ramayya received her MBBS from Lady Hardinge Medical College and Hospital, University of Delhi, New Delhi, India, in 1970, and her Diploma in Child Health from The College of Physicians and Surgeons of Bombay the next year. Following her postgraduate work in Bombay, she served as senior house surgeon (pediatrics) at the Institute of Child Health in Hyderabad, India (1973), and as senior house officer (pediatrics) at the Sorrento Maternity Hospital (1974) and at the Selly Oak Hospital (1975) in Birmingham, UK. She started her pediatric residency in the United States in 1976 at Cook County Children's Hospital, Chicago, Illinois, and continued her residency the following year at the University of South Florida in Tampa. Her residency was followed by a five-year fellowship in Pediatric Endocrinology at the University of Washington in Seattle (1978 - 1983), and three years as a clinical associate at the National Institute of Child Health and Human Development at the National Institutes of Health (1993 - 1996). She also functioned as a consultant in Pediatric endocrinology on the MEDCON team of University of Washington (1980 - 1992). In 1994, she received a Masters Degree in Administrative Medicine from the University of Wisconsin. Immediately prior to joining the Tulane faculty, she practiced general pediatrics and pediatric endocrinology in the Greater Seattle area and was a consultant in pediatric endocrinology at the Swedish Medical Center in Seattle. In addition, she worked as a Research Scientist in the Department of Surgery at the Children's Hospital and Regional Medical Center, Seattle (1998 - 2000), and collaborated with investigators at the Fred Hutchinson Cancer Research Center in Seattle as a visiting scientist in the Division of Human Biology Program in Cancer Biology (2000 - 2004). Dr. Ramayya's research interests are in the biology of endocrine-related tumors. She had excellent research training at the NIH, and while at the NIH she cloned the human Steroidogenic Factor-1 (hSF-1) gene and studied its expression in human tissues. She is a recipient of travel grant awards from The Endocrine Society and the Lawson Wilkins Pediatric Endocrine Society for her work in the area of hSF-1. At Tulane, she plans to develop an independent research career in molecular signaling in breast and ovarian cancers.
Associate Professor of Community Health Sciences
diego@tulane.edu
(504) 988-5742
1430 Tulane Ave., Box SL-29, New Orleans, LA 70112-2699
Associate Professor of Structural and Cellular Biology (Anatomy)
TCC Program Member
browan@tulane.edu
(504) 988-1365
1430 Tulane Ave., Box SL-49, New Orleans, LA 70112-2699
Dr. Rowan's faculty listing and research interests on the SCB website:
http://www.som.tulane.edu/anatomy/faculty/browan.htm
Biographical Narrative:
Dr. Rowan received his Ph.D. in pharmacology and cancer therapeutics from the State University of New York at Buffalo in 1994. His thesis research involved Structural and Functional Characterization of Glucocorticoid Receptors in the P1798 Mouse Lymphosarcoma. From 1994 - 2000, he was a postdoctoral fellow in Molecular and Cellular Biology at Baylor College of Medicine in Houston, TX. In 2000, he joined the faculty of the Medical College of Ohio in Toledo as an assistant professor in the Biochemistry and Molecular Biology Department. Dr. Rowan has several awards to his credit, including the Sigma Xi Award for Excellence in Research, 1988, and the American Association for Cancer Research Young Investigator Scholar Award, 1999 and 2000. He is a reviewer for several medical journals, including Cancer Research, Endocrinology, Journal of Biological Chemistry, Molecular Cell, Molecular and Cellular Biology, Molecular Endocrinology and Steroids, and is a member of the American Association for Cancer Research and the Endocrine Society. Dr. Rowan joins the Tulane University Health Sciences Center faculty as Associate Professor in the Department of Structural and Cellular Biology. His research seeks to define the molecular mechanisms governing steroid receptor action in normal and disease states of female reproductive tissues with the aim of developing new therapies and improving existing therapies for breast cancer, gynecological malignancies, contraception and postmenopausal hormone replacement therapy.
Research Interests
Recent Publications:
- Rowan BG, Weigel NW, O'Malley BW. Phosphorylation of steroid receptor coactivator one: identification of the phosphorylation sites and phosphorylation through the mitogen activated protein kinase pathway. J Biol Chem 275: 4475. (2000)
- Rowan BG, Garrison N, Weigel NL, O'Malley BW. 8-Bromo-cyclic AMP induces phosphorylation of two sites in SRC-1 that facilitate ligand-independent activation of the chicken progesterone receptor and are critical for functional cooperation between SRC-1 and CREB binding protein. Mol Cell Biol 20(23):8720-30 (2000)
- Kelley KM, Rowan BG, Ratnam M. Positive regulation of folate receptor alpha by estrogen receptor antagonists via G-rich element: implications in tumor targeting. Cancer Res 63(11):2820-8 (2003)
- Rowan BG, Narayanan R, Weigel NL. Analysis of receptor phosphorylation. Methods Enzymol, 364:173-202. (2003)
- Kershah SM, Desouki MM, Koterba KL, Rowan BG. Expression of estrogen receptor coregulators in normal and malignant human endometrium. Gynecol Oncol 92(1):304-13 (2004)
- Desouki MM, Rowan BG. SRC kinase and mitogen-activated protein kinases in the progression from normal to malignant endometrium. Clin Cancer Res 15;10(2):546-55 (2004)
- Shah YM, Basrur V, Rowan BG. Selective estrogen receptor modulator regulated proteins in endometrial cancer cells. Mol Cell Endocrinol 219(1-2):127-39 (2004)
- Shah Y, Rowan BG. The Src Kinase Pathway Promotes Tamoxifen Agonist Action through Phosphorylation-Dependent Stabilization of Estrogen Receptor alpha Promoter Interaction and Elevated SRC-1 Activity. Mol Endocrinol 19(3):732-48. (2005)
- Basu A, Rowan BG. Genes related to estrogen action in reproduction and breast cancer. Frontiers Biosci, in press. (2005)
- Shah Y, Kaul A, Dong Y, Ip C, Rowan BG. Selenium inhibits estrogen receptor signaling in breast cancer through decreased expression of estrogen receptor alpha mRNA. Breast Cancer Res Treat, in press. (2005)
- Shah Y, Al-Dhaheri M, Dong Y, Ip C, Rowan BG. Selenium disrupts estrogen receptor alpha signaling and restores tamoxifen sensitivity in tamoxifen resistant breast and endometrial cancer cells. Accepted to Mol Cancer Therapeutics. (2005)
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