Kahn, Kandil, Karam, Kendall, Kim, Korndorffer, Krause, Krogstad, Kruse-Jarres, Koochekpour
Marc J. Kahn, M.D.Professor of Medicine
Section of Hematology and Medical Oncology
Associate Dean for Student Affairs
TCC Contributing Member
mkahn@tulane.edu
(504) 988-5331, (504) 988-6462 fax
1430 Tulane Ave., Box SL-67, New Orleans, LA 70112-2699
Curriculum Vitae (in Adobe Acrobat PDF format; see PDF help)
Assistant Professor, Department of Surgery, Section of Endocrine and Oncological Surgery
Section Chief, Endocrine Surgery
TCC Associate Member
ekandil@tulane.edu
(504) 988-7407, (504) 988-1874 fax
1430 Tulane Ave., Box SL-22, New Orleans, LA 70112-2699
Biographical Narrative:
Dr. Kandil completed his general surgical training at State University of New York (SUNY) Health Sciences Center - Downstate and then completed a clinical fellowship in the Division of Endocrine and Oncological Surgery at Johns Hopkins University Hospital. He also completed two research fellowships at New York University and SUNY. Dr. Kandil has a strong research interest in endocrine diseases, particularly endocrine tumor genetics and clinical outcome research for endocrine organ neoplasia. His prior research interests included investigation of the basic mechanisms underlying pancreatic injury and glucose metabolism. His major clinical responsibilities include robotic and laparoscopic adrenal and endocrine pancreas surgery; laparoscopic colorectal surgery; trans-anal and endoscipic microsurgery (TEM); establishing an ultrasound biopsy clinic for thyroid cancer; establishing a specialty endocrine surgery clinic at University Hospital; and establishing the program for minimally invasive endocrine and oncological surgery, including video assisted surgery for thyroid diseases and minimally invasive and video assisted surgery for parathyroid diseases.
Selected Publications:
- Kandil E, Burack J, Sawas A, Bibawy H, Schwartzman A, Zenilman ME. B-type naturetic peptide (BNP): a biomarker for the diagnosis and risk stratification of patients with septic shock. Arch Surg, 143(3): 242-6, 2008.
- Burack JH, Kandil E, Sawas A, Oneil PA, Sclafani SJ, Lowery RC, Zenilman ME. Triage and outcome of patients with mediastinal penetrating trauma. Ann Thorac Surg, 83(2): 377-82, 2007.
- Kandil E, Lin YY, Bluth MH, Zhang H, Levi G, Zenilman ME. Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins. World J Gantroenterol, 12(42): 6806-6811, 2006.
- Kandil E, Bluth MH, Mueller CM, Shah V, Lin YY, Zhang H, Dresner L, Lempert L, Nowakowski M, Gross R, Schulze R, Zenilman ME. Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsis. Critical Care Med, 34: 188-195, 2006.
- Lopez J, Kandil E, Schwartzman A, Zenilman ME. Appendiceal mucocele: benign or malignant? Surgical Rounds, 29(11), 540-544, 2006.
- Zhang H, Kandil E, Lin YY, Levi G, Zenilman ME. Targeted inhibition of gene expression of pancreatitis-associated proteins exacerbates the severity of acute pancreatitis in rats. Scand Journal of Gastroenterology, 39(9): 870-881, 2004.
- Zhang H, Patel SA, Kandil E, Mueller CM, Zenilman ME. Pancreatic elastase is proven to be a mannose-binding protein: implications for the systemic response to pancreatitis. Surgery, 133(6): 678-88, 2003.
- Kandil E, Lin Y, Bluth M, Zenilman M. Pancreatitis associated protein (PAP) genetic isoforms. Gastroenterology, 126, S2, pA782, 2004.
- Kandil E, Lin Y, Levi G, Bluth M, Zenilman M. Dexamethasone mediates protection against acute pancreatitis in rats via upregulation of pacreatitis-associated protein (PAP). Gastroenterology, 126, S2, pA781, 2004.
- Kandil E, Zhang H, Levi G, Lin Y, Nemes C, Viterbo D, Callender G, Zenilman M. Pancreatitis-associated protein is protective against acute pancreatitis. Gastroenterology, 124(4), Suppl. #1, A-95, 738, 2003.
- Kandil E, Burack J, Schwartzman A, Zhang H, Bibawy H, Elabbasi W, Zenilman ME. Myocardial stress during septic shock produces elevated levels of brain naturetic peptide. Circulation, 108(17):IV p397, #1835, 2003.
- Kandil E, Zhang H, Beckles D, Lin Y, Callender G, Mueller C, Ocasio V, Zenilman ME. Decreased Reg I expression underlies age-related impairment of glucose tolerance. J. Surg Res, 114(2): 292, 2003.
- Kandil E, Campbell C, Tufaro AP. Rectus abdominus intramuscular hemangioma. Archives of Surgery, in press.
- Bluth MH, Mueller CM, Pierre J, Callender G, Kandil E, Viterbo D, Fu SL, Sugawara A, Okamoto H, Zenilman ME. Pancreatic reg I in chronic pancreatitis and aging: implications for new therapeutic approaches to diabetes. Pancreas, in press.
- Kandil E, Tufaro A, Carson K, Lin F, Somervell H, Farrag T, Dackiw A, Zeiger M, Tufano R. Plasma 25-hydroxyvitamin D levels correlate with severity of primary hyperparathyroidism and parathyroid adenoma localization on sestamibi scans. Archives of Otolaryngology - Head & Neck Surgery, in press.
Professor and Chairman of Biochemistry
TCC Contributing Member
karamoff@tulane.edu
Homepage on the Biochemistry website:
www.tulane.edu/~biochem/faculty/karam.htm
(504) 988-1995, (504) 988-1611 fax
1430 Tulane Ave., Box SL-43, New Orleans, LA 70112-2699
Biographical Narrative:
Dr. Karam received his B.S. in Biology/Chemistry from the American University of Beirut, Lebanon in 1958. He carried out his doctoral studies in Biochemistry with Dr. Edward Glassman at the University of North Carolina, Chapel Hill, receiving his Ph.D. in 1965. His postdoctoral studies were carried out with Dr. Joseph F. Speyer at the Cold Spring Harbor Laboratory in New York. In 1967 he became Research Assistant Professor of Genetics and Cell Biology at the University of Connecticut at Storrs and in 1968 moved to Sloan-Kettering Institute for Cancer Research in New York City as a Research Associate. In 1971 Dr. Karam joined the faculty at the Medical University of South Carolina where he attained the rank of professor. He was appointed to his current position as Professor and Chair of the Department of Biochemistry in the School of Medicine at Tulane University Health Sciences Center in November, 1991. The primary focus of Dr. Karam's research is on the genetic and biochemical mechanisms that regulate the multiprotein DNA replication machine (DNA replisome) of bacteriophage T4 and the T4-related phages. These bacterial viruses encode all of the proteins required for assembly of the viral replisome and replication of the ~170,000 base-pair (bp) linear and circularly permuted DNA genome. Complexity of the T4 replisome resembles that of many large pathogenic DNA viruses, like the herpes, vaccinia, and adeno viral groups At the core of the T4 DNA replisome is the replicative DNA polymerase, product of phage gene 43 (gp43), which works in a complex with a large number of other proteins to affect rapid and accurate genome replication in the phage-infected Escherichia coli host. T4 gp43 carries several functions in its single polypeptide chain, including two catalytic activities that work together to control fidelity of replicative DNA synthesis. These two activities are the polymerase (DNA synthesizing) activity, which determines fidelity of nucleotide base selection and rate of DNA chain extension, and the editing or proofreading (3'-exonuclease) activity, which removes misincorporated bases. Studies in Dr. Karam's laboratory are determining how these two activities of the enzyme are coordinated to maintain low mutation rates. Other studies are addressing relationships between two types of nucleic-acid binding functions of this DNA polymerase. The nucleotide-sequence independent DNA binding activity used for phage DNA replication and a highly specific RNA binding activity through which the enzyme binds its own mRNA and regulates its own biosynthesis at the level of translation are both being studied. Recent results suggest that this viral enzyme uses RNA as a scaffold to build the multiprotein replisome. Experimental tools are being generated to find out if cellular and other viral DNA polymerases also use specific RNA to initiate replisome assembly.
Selected Publications:
- Wang J., Sattar AK, Wang CC, Karam JD, Konigsberg WH, Steitz TA. Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Cell 89: 1087-1099 (1997)
- Dressman HK, Wang CC, Karam JD and Drake JW. Retention of replication fidelity by a DNA polymerase functioning in a distantly related environment. Proc Natl Acad Sci USA 94: 8042-8046 (1997)
- Yeh LS, T. Hsu and Karam JD. Divergence of a DNA replication gene cluster in the T4-related bacteriophage RB69. J Bacteriol 180: 2005-2013 (1998)
- Yang G, Lin T, Karam JD, Konigsberg WH.Steady-state kinetic characterization of RB69 DNA polymerase mutants that affect dNTP incorporation. Biochemistry 38: 8094-8101 (1999)
- Pavlov AR, Karam JD. Nucleotide-sequence-specific and non-specific interactions of T4 DNA polymerase with its own mRNA. Nucleic Acids Res 28: 4657-4664 (2000)
- Bebenek A, Dressman HK, Carver GT, Ng S, Petrov V, Yang G, Konigsberg WH, Karam JD, Drake JW. Interacting fidelity defects in the replicative DNA polymerase of bacteriophage RB69. J Biol Chem 276: 10387-10397 (2001)
Carl Kendall, Ph.D.
Acting Chairman and Associate Professor of International Health and Development
TCC Contributing Member
ckendall@tulane.edu
(504) 988-3655, (504) 988-3653 fax
1430 Tulane Ave., Box SL-29, New Orleans, LA 70112-2699
Faculty listing on the IHD website:
http://www.tulane.edu/~inhl/faculty.shtml#Carl Kendall
Biographical Narrative:
Carl Kendall, PhD is a Professor and Acting Chair of the Tulane University Department of International Health and Development. Dr. Kendall rejoined Tulane after a two-year sabbatical as the Director of the Maternal and Child Epidemiology Unit at the London School of Hygiene and Tropical Medicine. Prior positions include Chief of the Behavioral Research Unit, AIDS Control and Prevention Project (AIDSCAP), Family Health International and Director, Center for International Community-based Health Research, Department of International Health, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland. Dr. Kendall has served as a member of numerous professional panels related to the AIDS/HIV pandemic and is on the Governing Council of the American Public Health Association. He is a frequent consultant to AIDS/HIV and child health programs in Latin America, Africa and Asia.
Jong Kim
Assistant Professor of Pathology
Positions and Employment
- 1986-1987 Research Associate, Livestock Experiment Station, Suwon, Korea
- 1987-1988 Rotary International Foundation Scholarship, Dept. of Dairy Science, Virginia Tech
- 1988-1994 Graduate Research Assistant, Department of OB/GYN, East Tennessee State University
- 1994-1997 Postdoctoral Fellow, Department of Gynecology and Obstetrics, Emory University
- 1997-1999 Instructor, Department of Gynecology and Obstetrics, Emory University
- 1999-2004 Research Associate (postdoc), USDA, ARS, U.S. Meat Animal Research Center
- 2004-present Assistant Professor of Pathology, School of Medicine, Stanley S. Scott Cancer Center
LSUHSC-New Orleans - 2005-present Graduate Faculty, School of Graduate Studies, LSUHSC-New Orleans
Selected Publications:
- Kim JG, Vallet JL. 2007. Placental expression of the membrane form of folate binding protein during pregnancy in swine. Theriogenology. 67(7):1279-84.
- Kim JG, Nonneman D, Vallet JL, Wise TH, Rohrer GA. 2006. Sequence variation and evaluation of inhibin α-subunit (INHA) and steroidogenic acute regulatory protein (STAR) for reproductive traits in swine. Animal Genetics. 37:424-425.
- Kayser JP, Kim JG, Cerny RL, Vallet JL. 2006. Global characterization of porcine intrauterine proteins during early pregnancy. Reproduction. 131(2):379-88.
- Kim JG, Nonneman D, Vallet JL, Rohrer GA, Christenson RK. 2005. Linkage mapping of the porcine chromogranin B (CHGB) gene to chromosome 1. Animal Genetics. 36(2):168.
- Kim JG, Nonneman D, Vallet JL, Rohrer GA, Christenson RK. 2005. Linkage mapping of the porcine myelin basic protein (MBP) gene to chromosome 8. Animal Genetics. 36(2):163-4.
- Kim JG, Rohrer GA, Vallet JL, Christenson RK, Nonneman D. 2004. Addition of fourteen anchored loci to the porcine chromosome 8 comparative map. Animal Genetics. 35(6):474-6.
- Kim JG, Vallet JL. 2004. Secreted and placental membrane forms of folate binding protein occur sequentially during pregnancy in swine. Biology of Reproduction. 71(4):1214-9.
- Kim JG, Vallet JL Nonneman D, Christenson RK. 2004. Molecular cloning and endometrial expression of porcine high density lipoprotein receptor SR-BI during the estrous cycle and early pregnancy. Molecular Cellular Endocrinology 222:105-112.
- Kim JG, Vallet JL, Christenson RK. 2003. Molecular cloning and endometrial expression of porcine amphiregulin. Molecular Reproduction and Development 65:366-372.
- Kim JG, Song JH, Vallet JL, Rohrer GA, Johnson GA, Joyce MM, RK Christenson. 2003. Molecular characterization of porcine bone morphogenetic protein receptor-1B. Biology of Reproduction 68(3):735-743.
- Kim JG, Nonneman D, Rohrer GA, Vallet JL, Christenson RK. 2003. Linkage mapping of a SNP in the porcine MADH1 gene to a region of chromosome 8 that contains QTL for uterine capacity. Animal Genetics 34:310-311.
- Kim JG, Smith TPL, Snelling WM, Vallet JL, Christenson RK. 2003. Linkage mapping of the bovine bone morphogenetic protein receptor-1B (BMPR-1B) to chromosome 6. Animal Genetics 34:311.
- Kim JG, Nonneman D, Vallet JL, Christenson RK. 2003. Linkage mapping of the porcine testis enhanced gene transcript (TEGT) gene to chromosome 5. Animal Genetics 34:152-153.
- Kim JG, Vallet JL, Rohrer GA, Christenson RK. 2002. Characterization of porcine uterine estrogen sulfotransferase. Domestic Animal Endocrinology 23(4): 493-506.
- Kim JG, Nonneman D, Vallet JL, Christenson RK. 2002. Mapping of the porcine alpha-fetoprotein (AFP) gene to swine chromosome 8. Animal Genetics 33(6):471-2.
- Kim JG, Nonneman D, Vallet JL, Rohrer GA, Christenson RK. 2002. Linkage mapping of a SNP in the porcine QDPR gene to chromosome 8. Animal Genetics 33(6):474.
- Kim JG, Vallet JL, Rohrer GA, Christenson RK. 2002. Mapping of the porcine AREG and EGF genes to SSC8. Animal Genetics. 33 (4): 314-5.
- Kim JG, Vallet JL, Christenson RK. 2001. Characterization of uterine epidermal growth factor during early pregnancy in pigs. Domestic Animal Endocrinology. 20(4): 253-265.
- Yoon HG, Yoon SH, Son WY, Kim JG, Im KS, Lim JH. 2001. Alternative embryo transfer on day 3 or day 5 for reducing the risk of multiple gestations. Journal of Assist Reprod Genet. 18(5):262-7.
- Kim JG, Ramachandran S, Zhou HM, Rayner DB, Parthasarathy S. 2000. Implications in the maintenance of pregnancy: I. Presence of immunoreactive glycodelin in human umbilical cord vein endothelial cells. Fertility and Sterility. 73:839-842.
- Zhou HM, Ramachandran S, Kim JG, Rayner DB, Rock JA, Parthasarathy S. 2000. Implications in the management of pregnancy: II. Low levels of gene expression but enhanced uptake and accumulation of umbilical cord glycodelin. Fertility and Sterility. 73:843-847.
- Kim JG, Taylor WR, Parthasarathy S. 1999. Demonstration of the presence of lipid peroxidemodified proteins in human atherosclerotic lesions using a novel lipid peroxide-modified anti-peptide antibody. Atherosclerosis. 143:335-340.
- Poddar A, Kim JG, Gill KP, Bates BN, Santanam N, Rock JA, Murphy AA, Parthasarathy S. 1998. Generation and characterization of a polyclonal anti-peptide antibody to human glycodelin. Fertility and Sterility. 69:543-548.
- Kim JG, Sabbagh F, Santanam N, Wilcox JN, Medford RM, Parthasarathy S. 1997. Generation of a polyclonal antibody against lipid peroxide-modified proteins. Free Radical Biology and Medicine. 23(2):251-259.
- Kim JG, Rock JA, Murphy AA, Parthasarathy S. 1997. Charge-based interactions of mammalian sperm with oocytes: inhibition of fertilization of mouse oocytes by ligands of macrophage scavenger receptor(s). Fertil. Steril. 68:1108-1113.
- Kim JG, Keshava C, Murphy AA, Pitas RE, Parthasarathy S. 1997. Fresh mouse peritoneal macrophages have low scavenger receptor activity. J. Lipid Res. 38:134-142.
- Roudebush WE, Kim JG. 1992. Mouse embryo biopsy: Abnormal development with trophoblastic vesicle formation. J. Zool. Sci. 9(3):583-587.
- Roudebush WE, Kim JG, Minhas BS, Dodson MG. 1990. Survival and cell acquisition rates after preimplantation embryo biopsy: use of two mechanical techniques and two mouse strains. Am. J. Obstet. Gynecol. 162:1084-1090.
- Chung KM, Kim JG, Im KS. 1989. A study on the stages of embryos non-surgically recovered from heifers and cows in natural heat. Korean J. Emb. Trans. 4:41-45.
- Kim JG, Chung KM, Im KS, Lee YB. 1988. Effect of superovulation of immature and mature heifers on ovarian response, embryo production and pregnancy. Korean J. Anim.Sci. 30:276-284.
- Kim HS, Oh SJ, Yang BS, Yoo SH, Kim JG, Lee KS. 1986. A study on the factors affecting the survival of embryos transferred in cattle. Korean J. Anim.Sci. 28:578-583.
- Im KS, Lee YB, Chung KM and Kim JG. 1986. Studies on embryo transfer in cattle II. Studies on superovulation and conception of heifers in puberty. Agri. Res. Seoul Natl. Univ. 11:23-31.
- Kim HS, Oh SJ, Yang BS, Yoo SH, Kim JG, Baig SY, Lee KS. 1986. Studies on induction of superovulation and embryo transfer in cattle. Korean J. Emb. Trans. 1:69-75.
Associate Professor of Surgery
TCC Program Member
jkorndo@tulane.edu
(504) 988-2307
1430 Tulane Ave., Box SL-22, New Orleans, LA 70112-2699
John R. Krause, M.D.Professor and Chairman of Pathology and Laboratory Medicine
Director of Laboratories
Chief of Clinical Pathlogy
TCC Associate Member
jkrause@tulane.edu
(504) 988-5210, (504) 988-7839 fax
1430 Tulane Ave., SL-79, New Orleans, LA 70112-2699
Homepage on the Pathology website:
http://www.som.tulane.edu/departments/pathology/faculty/krause/krause.html
Biographical Narrative:
Dr. Krause received his B.S. from the Pennsylvania State University in 1962 and his M.D. from the University of Pittsburgh in 1966. He completed his pathology residency and hematopathology fellowship at the University of Pittsburgh Health Center Hospitals from 1966-1971. He has held academic positions at the Medical College of Pennsylvania, the University of Pittsburgh, and, since 1992, Tulane University School of Medicine. Since 1998, he has been Chair, Department of Pathology and Laboratory Medicine. Dr. Krause's research interests are in the field of hematopathology with particular interest in leukemias and lymphomas. Dr. Krause published one of the early books on the importance of the bone marrow biopsy in the evaluation of hematopathology disorders. He has extensive experience in the interpretation of bone marrow and lymph nodes specimens. He has developed and expanded our Flow Cytometry Facility and molecular diagnostic laboratory to aid in the interpretation of these disorders. Dr. Krause's current interests and research lie in the application of molecular techniques for diagnosis of malignant hematopathic neoplasms.
Selected Publications:
- Kahn MS, Krause JR. Intergrated hematopathology : Pairing clinician and pathologist in a second year medical school course. Pathol Ed 25: 17-21 (2000)
- Karavattahayyl S, Krause JR. Kimura's disease: A case report. ENTJ 79: 195-196 (2000)
- Krause JRKrause JR Morphology and classification of acute myeloid leukemias. Clin Lab Med 20: 1-16 (2000)
- Karavattahayyl S, Gaglio P, Garry RF, Krause JR, Dash S. Detecting of hepatitis C virus sequence in B-cell non-Hodgkin's lymphoma. Am J Clin Pathol 113: 391-398 (2000)
Donald J. Krogstad, M.D.
Henderson Professor and Chairman of Tropical Medicine
Director of the Center for Infectious Diseases
TCC Contributing Member
krogstad@tulane.edu
(504) 988-3558, (504) 988-6686 fax
1430 Tulane Ave., Box SL-17, New Orleans, LA 70112-2699
Biographical Narrative:
Dr. Krogstad received his undergraduate degree from Bowdoin College in Brunswick, Maine. He received his M.D. in 1969 from Harvard Medical School. After training at the Massachusetts General Hospital in Boston, he served at the Centers for Disease Control in Atlanta in Parasitic Diseases and as a Peace Corps Volunteer Physician in Lilongwe, Malawi. After serving at the Washington University School of Medicine for 14 years, Dr. Krogstad joined the Tulane faculty in June 1992 as Chair of Tropical Medicine, was invested as the Henderson Professor in 1994, and appointed Director of the Center for Infectious Diseases in 1998. Dr. Krogstad's current research is aimed at the molecular and genetic bases of resistance to chloroquine and quinine, structure-activity relationships among antimalarials, the development of a transfection system in Plasmodium falciparum and the use of plasmid constructs with a proline-rich amino acid linker to enhance the immunogenicity of cloned malaria parasite antigens. Field studies are centered in Mali and focus on three issues: optimal strategies for the use of chloroquine, techniques for the characterization of individual clones from polyclonal field isolates, and the development of methods to study pathogenicity and parasite virulence.
Selected Publications:
- De D, Krogstad FM, Cogswell FB, Krogstad DJ. Aminoquinolines that circumvent resistance in P. falciparum in vitro. Am J Trop Med Hyg 55: 579-583 (1996)
- Davison BB, Cogswell FB, Baskin GB, Falkenstein KP, Henson EW, Taranta AF, Krogstad DJ. Plasmodium coatneyi in the rhesus monkey (Macaca mulatta) as a model of malaria in pregnancy. Am J Trop Med Hyg 59: 189-201 (1998)
- Masinde GL, Krogstad DJ, Gordon DM, Duffy PE.Immunization with SPf66 and subsequent infection with homologous and heterologous parasites. Am J Trop Med Hyg 59: 600-605 (1998)
- De D., Krogstad FM, Byers LD, Krogstad DJ.Structure-activity relationships (SARs) for antiplasmodial activity among 7-substituted-4-aminoquinolines. J Med Chem 41: 4918-4926 (1998)
- Davison, B.B., Cogswell FB, Baskin GB, Falkenstein KP, Henson EW, Krogstad DJ. Placental changes associated with fetal outcome in the Plasmodium coatney/rhesus monkey model of malaria in pregnancy. Am J Trop Med Hyg 63:158-173 (2000)
- Doumbia S, Brown C, Doumbo O, Bagayoko M, Regens JL, Poudiougou B, Dicko A, Touré YT, Krogstad DJ. Cluster analysis of cerebral malaria and entomologic inoculation rates based on GIS/GPS data in the village of Bancoumana. Am J Trop Med Hyg (in press) (2002)
Assistant Professor of Medicine, Section of Hematology & Medical Oncology
TCC Contributing Member
rkruseja@tulane.edu
(504) 988-5433
1430 Tulane Ave., Box SL-78, New Orleans, LA 70112-2699
Selected Publications:
- Kruse-Jarres R, Moeller-Hadi C, Leissinger C. Inhibitor development and successful immune tolerance in an HIV infected patient with haemophilia A and after immune reconstitution with HAART. Haemophilia, 13(6): 707-11, 2007.
- Kruse-Jarres R, Leissinger C. Haemophilia after transjugular liver biopsy in a patient with severe haemophilia. Haemophilia, 11:642-643, 2005.
Shahriar Koochekpour
Assistant Professor
Positions and Employment
- 1996-1999:Postdoctoral Scientist, Molecular Oncology Section, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD.
- 2000-2001:Postdoctoral Fellow, Dept of Biochemistry and Molecular Biology, Stanley S.Scott Cancer Center, LSU-Health Sciences Center, New Orleans, LA.
- 2002-2005:Research-Assistant Professor, Department of Microbiology, Immunology, and Parasitology, Stanley S. Scott Cancer Center, LSU Health Sciences Center, New Orleans, LA.
- 2005-pres:Assistant Professor (tenure-track), Department of Microbiology, Immunology, and Parasitology, Stanley S. Scott Cancer Center, LSU Health Sciences Center, New Orleans, LA.
- 2006-pres: Adjunct Assistant Professor, Department of Biochemistry and Molecular Biology,
LSU Health Sciences Center, New Orleans, LA. - 2008-pres: Adjunct Assistant Professor of Urology, Department of Urology, LSU Health Sciences Center, New Orleans, LA.
Selected Publications:
- Koochekpour, S., Merzak, A., Pilkington, G.J. Vascular endothelial growth factor production is stimulated by gangliosides and TGF-ß isoforms in human glioma cells in vitro. Cancer Letters, 102:209-215, 1996.
- Koochekpour, S., Jeffers, M., Rulong, S., Taylor, G., Klineberg, E., Hudson, E.A., Resau, J.H., and Vande Woude, G.F. Met and Hepatocyte Growth Factor expression in Human Gliomas. Cancer Research, 57:5391-5398, 1997.
- Jeffers, M., Koochekpour, S., Fiscella, M., Sathyanarayana., and Vande Woude, G.F. Signaling Requirements for Oncogenic Forms of the Met Tyrosine Kinase receptor. Oncogene, 17:2691-2700, 1998.
- Koochekpour, S., Jeffers, M., Wang, P.H., Gong, C., Taylor, G.A., Roessler, L.M., Stearman, R., Stetler-Stevenson, W.G., Kaelin Jr., W.G., Linehan, W.M., Klausner, R.D., Gnarra, J.R., and Vande Woude, G.F. The VHL Tumor Suppressor Gene Inhibits HGF/SF-Induced Invasion and Branching Morphogenesis in Renal Carcinoma Cells. Mol Cell Biol, 19:5902-5912, 1999.
- Webb, C. P., Hose, C. D., Koochekpour, S., Jeffers, M., Oskarsson, M., Sausville, E., Monks, A., and Vande Woude, G.F. The geldanamycins are potent inhibitors of the HGF/SF-Met-uPA-Plasmin proteolytic network. Cancer Research, 60:342-349, 2000.
- Duesbery, N.S., Resau, J., Webb, C. P., Koochekpour, S., Koo, H. M., Leppla, S.H., and Vande Woude, G.F. Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways. Proc Natl Acad Sci. USA, 98: 4089-4094, 2001.
- Koochekpour, S., Maresh, G., Katner, A., Parker-Johnson, K., Lee, T-J., Hebert, F. E., Kao, Y., and Rayford, W. Establishment and characterization of a primary African-American prostate cancer cell line, E006AA. Prostate, 60:141-152, 2004.
- Koochekpour, S., Sartor, O., Lee, T-J., Zieske, Arthur., Patten, D. Y., Hiraiwa, M., Sandhoff, K., Remmel, N., and Minokadeh, A. Prosaptide TX14A stimulates growth, migration, and invasion and activates the Raf-MEK-ERK-RSK-Elk-1 signaling pathway in prostate cancer cells. Prostate, 61:114-123, 2004.
- Sartor, O and Koochekpour, S. Stem Cells and Prostate Cancer. Clin Prostate Cancer, 3:11- 12, 2004.
- 10. Lee, T-L., Luftig, R., Sartor, O., and Koochekpour, S. Saposin C Promotes Survival and Prevents Apoptosis Via the PI3K/Akt-Dependent Pathway in Prostate Cancer Cells. Mol Cancer, 3: 31, 2004.
- Koochekpour, S., Sartor, O., Hiraiwa, M., Lee, T-L., Rayford, W., Remmel, N, Sandhoff, K., Minokadeh, A., and Patten, D. Y. Saposin C Stimulates Growth and Invasion, Activates p42/44 and SAPK/JNK Signaling Pathways of MAPK and Upregulates uPA/uPAR Expression in Prostate Cancer and Stromal Cells. Asian J Andrology, 7, 147-158, 2005.
- Gandhok, N. K., Looney S., Koochekpour, S., and Sartor, O. Relationships between reverse transcriptase-polymerase chain reaction for prostate specific antigen, survival, and various prognostic laboratory factors in patients with hormone refractory prostate cancer. Urol Oncol, 23:163-167, 2005.
- Koochekpour, S., Lee, T-J., Beroukhim, R., Hssieh, C-L., Hofer, M. D., Zhau, H. E, Hiraiwa. M., Sawyers, C.L., Luftig, R. B., Sandhoff, K., Pienta, K. J., Rubin, M. A., Sellers, W. R., and Sartor, O. Amplification and Overexpression of Prosaposin in Prostate Cancer and Other Malignant Cells. Genes, Chromosomes & Cancer, 44:351-64, 2005.
- Koochekpour,S. PSAP (Prosaposin; Gene Card/Invited-Review Article) variant Gaucher disease)). URL:http://www.infobiogen.fr/services/chromcancer/Genes/PSAPID42980ch10q22.html. Atlas Genet Cytogenet Oncol Haematol, 10:370-384, 2006.
- Koochekpour, S., Lee, T-J., Wang, R, Culig, Z., Delorme, N., Caffey, S., Marrero, L., and Aguirre, J. Prosaposin Upregulates AR and PSA Expression and Activity In Prostate Cancer Cells (LNCaP). Prostate, 67:178-189, 2007.
- Koochekpour, S., Lee, T-J, Wang, R., Sun, Y., Delorme, N., Hiraiwa, M., Grabowski, G. A., Culig, Z., and Minokadeh, A. Prosaposin is a novel androgen-regulated gene in prostate cancer cell line LNCaP. J Cell Biochem, 110: 631-641, 2007.
- Nair, S. S., Guo, Z., Mueller, J. M, Koochekpour, S., Qiu, Y., Tekmal, R. R, Schule, R., Kung, H. J, Kumar, R, Vadlamudi RK. PELP1/MNAR enhances androgen receptor functions through LIM-only coactivator FHL2. Mol Endocrinol. 21: 613-624, 2007.
- Koochekpour, S., Lee, T-J., Sun, Y., Hu, S., Grabowski, G. A., Liu, Z., Garay, J. Prosaposin is an AR-target gene and its neurotrophic domain upregulates AR expression and activity in prostate stromal cells.
J Cell Biochem, 14, 104(6): 2272-2285, 2008.
|
||||||||||||
Information for Researchers |
 |
| more info » |