Iosipiv, Izumi
Igor V. Iiosipiv, M.D.
See Ihor V. Yosypiv, M.D.
Tadahide Izumi
Assistant Professor
Positions and Employment
- 1993-1998: Postdoctoral Associate, Sealy Center for Molecular Science, University of Texas Medical
Branch, Galveston, TX. - 1998-2004: Assistant Professor, Sealy Center for Molecular Science and Department of Human Biological
Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX - 2004-present : Assistant Professor, Department of Otorhinolaryngology; Adjunct member of Department of
Biochemistry & Molecular Biology; Stanely S. Scott Cancer Center - Louisiana State University Health Sciences Center, New Orleans, LA 70112
Positions and Employment
- 1. Izumi, T., Ishizaki, K., Ikenaga, M., Yonei, S. (1992) A mutant endonuclease IV of E. coli loses the ability to repair lethal DNA damage induced by hydrogen peroxide but not that induced by methyl methanesulfonate. J. Bacteriol. 174: 7711-7716.
- Tatsuka, M., Ibeanu, G.C., Izumi, T., Narayan, S. Ramana, C. V., Kim, N. K., Kang, W., Roy, G., and Mitra, S. (1995) Structural organization of the mouse DNA repair gene, N-methylpurine-DNA glycosylase. DNA and Cell Biology 14: 37-45.
- Izumi, T., Henner, W. D., and Mitra, S. (1996) Negative regulation of the major human APendonuclease, a multifunctional protein. Biochemistry 35: 14679-14683.
- Mitra, S., Hazra, T. K., Roy, R., Ikeda, S., Biswas, T., Lock, J., Boldogh, I., and Izumi, T. (1997) Complexities of DNA base excision repair in mammalian cells. Mol. Cells. 7: 305-312.
- Izumi, T., Tatsuka, M., Tano, K., Asano, M., and Mitra, S. (1997) Molecular cloning and characterization of the promoter of the human N-methylpurine-DNA glycosylase (MPG) gene. Carcinogenesis 18: 1837-1839.
- Roy, R., Biswas, T, Hazra, T. K., Roy, G., Grabowski, D. T., Izumi, T., Srinivasan, G., and Mitra, S. (1998) Specific Interaction of wild type and truncated mouse N-methylpurine-DNA glycosylase with ethenoadenine-containing DNA. Biochemistry 37: 580-589.
- Izumi, T. and Mitra, S. (1998) Deletion analysis of human AP-endonuclease: Minimum sequence required for the endonuclease activity. Carcinogenesis 19: 525-527.
- Ramana, C. V., Boldogh, Izumi, T., and Mitra, S. (1998) Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc. Natl. Acad. Sci. USA 95: 5061-5066.
- Takemoto, T., Zhang, Q.M., Matsumoto, Y., Mito, S., Izumi, T., Ikehata, H., and Yonei, S. (1998) 3’- Blocking damage of DNA as a mutagenic lesion caused by hydrogen peroxide in Escherichia coli. J. Radiat. Res. 39: 137-144.
- Mitra, S., Izumi, T., Boldogh, I., Ramana, C. V., Hsieh, CC, Saito, H., Lock, and J., Papaconstantinou, J. (1999) Repair of oxidative DNA damage and aging: central role of APendonuclease. Proc. NATO Asi. Monograph. Prenum Press, 295-311.
- Ikeda, S., Biswas, T., Roy, R., Izumi, T., Boldogh, I., Kurosky, A., Sarker A. H., Seki, S., and Mitra, S. (1998) Purification and characterization of a human homolog (hNTH1) of Escherichia coli endonuclease III: Direct identification of Lys-212 as the nucleophilic active site. J. Biol. Chem. 273: 21585-21593
- Johnson, R. E., Torres-Ramos, C. A., Izumi, T., Mitra, S., Prakash, S., and Prakash, L. (1998) Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites Gene. Dev. 12: 3137-3143.
- Edwards, M., Rassin, D. K., Izumi, T., Mitra, S., and Perez-Polo, J. R. (1998) APE/Ref-1 responses to oxidative stress in aged rats. J. Neurosci. Res. 54: 635-638.
- Edwards, M., Kent, T. A., Rea, H. C., Wei, J., Quast, M., Izumi, T., Mitra, S., and Perez-Polo, J. R. 1998 APE/Ref-1 Responses to Ischemia in Rat Brain. Neuroreport 9: 4015-4018.
- Hazra, T. K., Izumi, T., Maidt, L., Floyd, R. A., and Mitra, S. (1998) The presence of two distinct 8- oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation. Nucleic Acids Res. 26: 5116-5122.
- Izumi, T., Malecki, J., Chaudhry, M. A., Hill, J. W., Weinfeld, M., Lee, J. C., and Mitra, S. (1999) Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease. J. Mol. Biol. 287: 47-57.
- Mol, C.D., Izumi, T., Mitra, S., and Tainer, J.A. (2000) Human APE1:DNA structures and mutants reveal abasic DNA binding to stage DNA repair. Nature 403: 451-456.
- Izumi, T., Hazra, T.K., Bolodogh, I., Park, M.S., Tomkinson, A., Park, M.S., Ikeda, S., and Mitra,S. (2000) Requirement of human AP-endonuclease in repair of DNA single-strand breaks by reactive oxygen species. Carcinogenesis 21: 1329-1334
- Hazra, T.K., Izumi, T., Venkataraman, R., Kow, Y. W., Dizdaroglu, M., and Mitra, S. (2000) Characterization of a novel 8-oxoguanine-DNA glycosylase in E. coli and Its identification as endonuclease VIII. J. Biol. Chem. ; 275:27762-27767
- Hill, J.W., Hazra, T.K., Izumi, T. and Mitra, S. (2001) Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential co-ordination of the initial steps in base excision repair. Nucleic Acids Res. 29:430-438.
- Mitra, S., Hazra, T., and Izumi, T. "Nucleic Acid Synthesis". In: Encyclopedia of Physical Science and Technology, Third Edition. Robert A. Myers (ed), Academic Press, San Diego, 2001
- Hazra TK, Hill JW, Izumi T, Mitra S. (2001) Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions. "Base Excision Repair 2001", Progress in Nucleic Acid Research and Molecular Biology, Academic Press, Moldave K, Mitra S, McCullough AK, Lloyd RS, Wilson SH., 68: 193-205
- Kuninger, D.K., Izumi, T., Papaconstantinou, J., and Mitra, S. (2002) Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease-1 promoter, Nucleic Acids Res., 30:823-829.
- Hazra, T.K., Izumi, T., Boldogh, T., Imhoff, B., Kow, Y.W., Jaruga, P., Dizdaroglu, M., and Mitra, S. (2002) Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA, Pro. Natl Acad Sci USA, 99:3523-3528
- Mitra, S., Izumi, T., Boldogh, I., Bhakat K.K., Hill, J.W., and Hazra T.K. (2002) Choreography of oxidative damage repair in mammalian genomes, Free Radic. Biol. Med., 33: 15-28.
- Hazra, T.K., Kow, Y.W., Hatahet, Z., Imhoff, B., Boldogh, I., Mokkapati, S.K., Mitra, S., and Izumi, T. (2002) Identification and characterization of a novel human DNA glycosylase for repair of cytosinederived lesions., J. Biol. Chem. 277: 30417-30420.
- Schein, C.H., Ozgun, N., Izumi T., and Braun, W. (2002) Total sequence decomposition distinguishes functional modules, "molegos" in apurinic/apyrimidinic endonucleases. BMC Bioinformatics, 3: 37-51.
- Hazra TK, Izumi T, Kow YW, Mitra S. (2003) The discovery of a new family of mammalian enzymes for repair of oxidatively damaged DNA, and its physiological implications. Carcinogenesis, 24:155- 157.
- Izumi. T., Wiederhold, L.R., Roy, G., Roy, R., Jaiswal, A., Bhakat, K.K., Mitra, S., Hazra, T.K. (2003) Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage. Toxicology, 193: 43-65.
- Bhakat, K., Izumi, T., Yang, S., Hazra, T., and Mitra, S. (2003) Role of acetylated human APendonuclease (APE1/Ref1) in regulation of the parathyroid hormone gene. EMBO J, 22: 6299-6309.
- Balazs, R., Izumi, T., Mitra, S. (2004) The Major Role of Human AP-endonuclease Homologue Apn2 in Repair of Abasic Sites in Schizosaccharomyces pombe. Nucleic Acids Res., 32: 1-12.
- Izumi, T., Schein, C.H., Oezguen, N., Feng, Y., Braun, W. (2004) Effects of backbone contacts 3' to the abasic site on the cleavage and the product binding by human apurinic/apyrimidinic endonuclease (APE1). Biochemistry, 43: 684-689.
- Wiederhold, L., Leppard, J.B., Kedar, P., Karimi-Busheri, F., Rasouli-Nia, A., Weinfeld, M., Tomkinson, A.E., Izumi, T., Prasad, R., Wilson, S.H., Mitra, S., Hazra, T.K. (2004) AP endonuclease-independent DNA base excision repair in human cells. Mol. Cell, 15, 209-220.
- Ding SZ, O'hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, Reyes VE, Ryan KA, Elliott SN, Izumi T, Boldogh I, Mitra S, Ernst PB, Crowe SE. (2004) Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells.
- Gastroenterology. 127:845-58.
- Izumi, T., Brown, D.B., Naidu, C.V., Bhakat K.K., MacInnes M.A., Saito H.., Chen, D.J., Mitra, S. (2005) Two essential but distinct functions of the mammalian AP endonuclease 1. Proc. Natl. Acad. Sci. USA 102: 5739-5743.
- Jackson, EB, Theriot, C.A., Chattopadhyay, R., Mitra, S., T. Izumi (2005) Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1). Nucleic Acids Res. 33:3303-3312.
- Chattopadhyay, R., Wiederhold, L., Szczesny, B., Boldogh, I., Hazra, T.K., Izumi, T., Mitra, S. (2006) Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells. Nucleic Acids Res., 34, 2067-2076
- Peddi, S.R., Chattopadhyay, R., Naidu, C.V., Izumi, T. (2006) The Human Apurinic/Apyrimidinic Endonuclease-1 Suppresses Activation of Poly(ADP-ribose) Polymerase-1 Induced By DNA Single Strand Breaks. Toxicology, 224, 44-55
- O'Hara, A.M., Bhattacharyya, A., Mifflin, R.C., Smith, M.F., Ryan, K.A., Scott, K.G., Naganuma, M., Casola, A., Izumi, T., Mitra, S., Ernst, P.B., Crowe, S.E. (2006) Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease- 1/redox factor-1. J Immunol. 177:7990-9.
- Mitra S, Izumi T, Boldogh I, Bhakat KK, Chattopadhyay R, Szczesny B. (2007) Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein. DNA Repair 6:461-469.
- Oezguen, N., C. H. Schein, S. R. Peddi, T. D. Power, T. Izumi, and W. Braun. (2007) A "moving metal mechanism" for substrate cleavage by DNA repair endonuclease APE-1. Proteins, 68:313-323
- Mantha, A.K., Oezguen, N., Bhakat, K.K., Izumi, T., Braun, W., Mitra, S. (2008) Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-Endonuclease 1. J Mol Biol. J Mol Biol. 379:28-37
- Zaky, A., Busso, C., Izumi, T., Chattopadhyay, R., Bassiouny, A., Mitra, S., Bhakat, K.K. (2008)
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in
response to DNA damage. Nucleic Acids Res. 36:1555-66.
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