Hill, Hong, Hopkins
Steven M. Hill, Ph.D.Edmond & Lily Safra Chair for Breast Cancer Research
Chairman of Structural and Cellular Biology (Anatomy)
TCC Program Member
smhill@tulane.edu
(504) 988-6456, (504) 988-1687 fax
1430 Tulane Ave., Box SL-49, New Orleans, LA 70112-2699
Homepage on the Anatomy website:
http://www.som.tulane.edu/anatomy/faculty.html
Dr. Hill received his B.S. in Biology from Abilene Christian University in 1980. He conducted his doctoral studies on the cellular mechanisms of the pineal hormone on growth of human breast cancer under the tutelage of Dr. David E. Blask at the University of Arizona, obtaining his Ph.D. in 1986. From 1986 to 1988 Dr. Hill was a postdoctoral fellow with the late Dr. William L. McGuire at the University of Texas Medical Center at San Antonio, working on the molecular mechanisms of estrogen-resistance in human breast cancer. In 1988 Dr. Hill returned to Abilene Christian University where he taught Anatomy/Physiololgy, Cell Biology, and Developmental Biology. In 1989 Dr. Hill joined Tulane University Health Sciences Center in the Department of Structural and Cellular Biology, where he is the course director for Medical Embryology. Dr. Hill has published over 60 manuscripts and book chapters in the area of molecular endocrinology and breast cancer. He is a reviewer for a variety of journals including Cancer Research, Breast Cancer Research and Treatment, and Molecular Endocrinology and has served on NIH, DOD, and NSF grant review panels. The primary focus of Dr. Hill's research is the molecular mechanisms of signal transduction cross- talk in breast cancer. Breast cancer is an endocrine-responsive neoplasm and as such is responsive to a variety of endocrine and growth factor stimuli. A complete understanding of the factors regulating the proliferation breast cancer, as well as an understanding of how these various hormones and factors cross-talk with each other to regulate breast cancer cell growth, is crucial to development of more potent breast cancer therapies. Dr. Hill's laboratory has conducted extensive studies examining the role of mutated estrogen receptors in the development of an estrogen-insensitive/tamoxifen-resistant phenotype in breast cancer. They have identified variant forms of the estrogen receptor that can function independent of hormone stimulation and can act to constitutively drive the mitogenic estrogen-response pathway in breast cancer. More recently, Dr. Hill's laboratory has demonstrated that the pineal hormone melatonin has significant inhibitory effects on the development and growth of human breast cancer. Furthermore, their studies have elucidated that melatonin can potentiate the actions of retinoic acid, a vitamin A derivative, to induce cell death in human breast tumor cells in culture, to prevent the development of carcinogen-induced breast cancer in rats and to induce the regression of over 70% of established breast tumors in rats. These studies currently are being moved into human clinical trials. Finally, Dr. Hill, in collaboration with investigators at Tulane Cancer Center and Xavier University, is examining the cross-talk of signaling pathways such as the melatonin receptor with the retinoic acid receptor and estrogen-receptor in both breast and prostate cancer and how these pathways can be manipulated to provide enhanced therapeutic advantage.
Selected Publications:
- Eck M, Yuan L, Duffy L, Ram PT, Ayettey S, Chen LL, Cohn CS, Reed JC, Hill SM. A sequential regimen of melatonin and all-trans retinoic acid induces apoptosis in Human Breast tumor cells. Br J Cancer 77: 2129-2137 (1998)
- Ram PT, Kiefer T, Silverman M, Song Y, Brown GM, Hill SM. Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth fractors. Mol Cell Endocrinol 141: 53-64 (1998)
- Hill SM, Teplitzky S, Ram PT, Kiefer T, Blask DE, Spriggs LL, Eck KE. Melatonin synergizes with retinoic acid in the prevention and regression of breast cancer. Adv Exp Med Biol 460: 345-62 (1999)
- Dai J, Kiefer T, Yuan L, Hill SM. Retinoid orphan receptor-alpha expression in human breast cancer and modulation of their transcriptional activity by the pineal hormone melatonin. Mol Cell Endorinol 176:111-120 (2001)
- Jones FE, Burow ME, Hill SM. Signal transduction in breast cancer: silencing the cross-talk. Eur Biopharmaceut Rev 70-73 (2003)
Assistant Professor of Community Health Sciences
TCC Contributing Member
trhong@tulane.edu
(504) 988-4535, (504) 988-3540fax
1440 Canal St., Ste. 2310., Box TW-19, New Orleans, LA 70112-2699
Biographical Narrative:
Dr. Hong received her Ph.D. at the Annenberg School of Communication at the University of Southern California, and a B.A. double major in communications and biology at the University of California at Davis. She is an assistant professor at the Department of Community Health Sciences and an Interdisciplinary Women's Health Research Faculty Scholar on the K12 Tulane BIRCWH program. Her research focuses on women's health, health communication and the use of communication technologies in health promotion and prevention. Her publications include an evaluation of tobacco promotion on the internet, efficacy of a media campaign to promote health outcomes, health information seeking behavior on the internet, the perceived credibility of health-related websites, and internet privacy.
Selected Publications:
- Hong T. The internet and tobacco cessation: the roles of internet self-efficacy and search task on the information-seeking process. Journal of Computer-Mediated Communication, 11(2), article 8. http://jcmc.indiana.edu/col11/issue2/hong.html, 2006.
- Hong T. Contributing factors to the use of health-related websites. Journal of Health Communication, 11(2): 149-165, 2006.
- Hong T. the influence of structural and message features on website credibility. Journal of the American Society for Information Science and Technology, 57:114-127, 2006.
- Hong T, Cody MJ. Presence of pro-tobacco messages on the web. Journal of Health Communication, 7:273-307, 2002.
- Reagan KA, Hong T, Cohen EL, Cody MJ. Blocking access to online tobacco sales sites. Tobacco Control, 11:164-165, 2002.
Professor of Practice, Cell and Molecular Biology
TCC Contributing Member
nhopkin@tulane.edu
(504) 862-3162, (504) 988-3540fax
2000 Percival Stern Hall, Tulane University, New Orleans, LA 70118
Biographical Narrative:
Dr. Hopkins received her B.S. in chemistry from Auburn University in 1970 and an M.S. in clinical pathology from the University of Alabama at Birmingham in 1973. After teaching at Loyola University in New Orleans for several years, she entered the doctoral program in the Chemistry Department at Tulane University in the laboratory of Dr. William Alworth and received her Ph.D. in 1992. She moved to the laboratories of Dr. William George and Dr. Juan Lertora in the Pharmacology Department at Tulane University School of Medicine. Her research interests are centered on the role of cytochrome P450 in both carcinogenesis and cancer chemoprevention. She is also interested in the role of natural products that are chemo-preventive in breast and prostate cancer. In collaboration with Dr. Maryam Foroozesh at Xavier University, she studies the inhibition of cytochrome P450 and the Akt pathway by natural product analogs. Dr. Hopkins is a member of the American Association of Cancer Researchers, the American Chemical Society, and the American Society of Biochemistry and Molecular Biology. She is also an associate member of the Society of Toxicology. She is on the National Council of Iota Sigma Pi Women's Chemistry Honorary Society.
Selected Publications:
- Hopkins NE, English N, Hughes V, Rowley CW, Wolf CR, Alworth WL. Induction of CYP 102 (cytochrome P450BM-3) in Bacillus megaterium by 17-beta estradiol and 4-sec-butylphenol. Biochem Biophys Res Commun, 244: 868-872, 1998.
- Shimada T, Yamazaki H, Foroozesh M, Hopkins N, Alworth WL, Guengerich FP. Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Chem Res Toxicol, 11: 1048-1056, 1998.
- Kobayashi Y, Stroble SM, Hopkins NE, Alworth WL, Halpert JR. Catalytic properties of an expressed cytochrome P450 2B1 from Wistar-Kyoto rat liver cDNA library. Drug Metab Dispos, 26: 1026-1030, 1998.
- Nikov GN, Hopkins NE, Boue S, Alworth WI. Interactions of dietary estrogens with human estrogen receptors and the effect on estrogen receptor-estrogen response element complex formation. Environ Health Perspect, 108: 867-872, 2000.
- Scott JF, Foroozesh M, Hopkins NE, Alekantis TG, Alworth WL. Inhibition of cytochrome P450 6D1 by alkylarenes, methylenedioxyarenes, and other substituted aromatics. Pestic Biochem Physiol, 67: 63-71, 2000.
- Rowley CW, Rajnarayanan RV, Hopkins NE, Alworth WL. Differential expression of CYP102 in Bacillus megaterium by 17-beta-estradiol and 4-sec-butylphenol. Biochem Biophys Res Commun, 300: 102-6, 2003.
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