A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Catling, Chen, Chiu, Church, Coy

Andrew D. Catling
Assistant Professor of Pharmacology

Positions and Employment:

  • 1988-1992 Graduate student with Dr, John Wyke, Beatson Institute for Cancer Research, Glasgow, Scotland.  PhD thesis titled “Conditional and dissociation mutants of pp60v-src ”.
  • 1992-1999. Post-doctoral Research Associate with Dr. Michael Weber, University of Virginia, Charlottesville, VA.  Regulation of ERK signaling.
  • 1999-2002. Research Assistant Professor of Microbiology, University of Virginia, Charlottesville, VA.  Molecular scaffolding in the ERK pathway, signaling and cell motility.
  • 2002-present. Assistant Professor of Pharmacology, Louisiana State University Health Sciences Center, New Orleans, LA. Molecular scaffolding in the ERK pathway, signaling and cell motility.

Selected Publications:

  • Catling, A. D., Wyke, J. A. and Frame, M. (1993)  Mitogenesis and transformation of quiescent chick fibroblasts by v-src : association with early changes in AP-1 function and dependence on events at the cell membrane.  Oncogene, 8:1875-1886.
  • Catling, A. D., Fincham, V. J., Frame, M. .J., Haefner, B. and Wyke, J. A. (1994)  Mutations in v-Src SH3 and catalytic domains jointly confer temperature-sensitive transformation with minimal temperature-dependent changes in cellular tyrosine phosphorylation.  J. Virol., 68:4392-4399.
  • Black, E. J., Catling, A. D., Kilbey, A., Woodgett, J. and Gillespie, D. A. F.        (1994)  Transcriptional activation by the v-Jun oncoprotein is independent of positive regulatory phosphorylation.  Oncogene, 9:2363-2368.
  • Jelinek, T., Catling, A. D., Reuter, C. W. M., Moodie, S. A., Wolfman, A., and Weber, M. J. (1994)  RAS and RAF form a signalling complex with MEK-1 but not MEK-2.  Mol. Cell Biol., 14: 8212-8218.
  • Catling, A. D., Reuter, C. W. M., Cox, M. E., Parsons, S. J. and Weber, M. J. (1994)  Partial purification of a Mitogen-activated protein kinase kinase activator from bovine brain: identifcation as B-RAF or a B-RAF-associated activity.  J. Biol. Chem., 269:30014-30021.
  • Reuter, C. W. M., Catling, A. D., and Weber, M. J. (1994)  Immune complex kinase assays for MAP kinase and MEK. Methods in Enzymology, 255:245-256.
  • Reuter, C. W. M., Catling, A. D., Jelinek, T., and Weber, M. J. (1995)  Biochemical analysis of MEK activation in NIH 3T3 fibroblasts: identification of B-Raf and other activators.  J. Biol. Chem., 270:7644-7655.
  • Catling, A. D., *Schaeffer, H-J., Reuter, C. W. M., Reddy, R., and Weber, M. J. (1995)  A proline-rich sequence unique to MEK1 and MEK2 is required for Raf binding and regulates MEK function.  Mol. Cell. Biol., 15:5214-5225.
  • Cox, M. E., Ely, C. M., Catling, A. D., Weber, M. J., and Parsons, S. J. (1996)  Tyrosine kinases are required for catecholamine secretion and mitogen-activated protein kinase activation in bovine adrenal chromaffin cells.  J. Neurochem., 66:1103-1112.
  • Egerton, M., Fitzpatrick, D. R., Catling, A. D., and Kelso, A. (1996)  Differential activation of T cell cytokine production by the extracellular signal-related kinase    (ERK) signaling pathway.  Eur. J. Immunol., 26:2279-2285.
  • Zecevic, M., Catling, A. D., Eblen, S. T., Renzi, L., Hittle. J. C., Yen, T. J., Gorbsky, G. J., and Weber, M. J. (1998)  Active MAP kinase in mitosis: localization and association with the motor protein CENP-E.  J. Cell Biol., 142:1547-1588.
  • *Schaeffer, H. J., *Catling, A. D., Eblen, S. T., Collier, L. S., Krauss, A., and Weber, M. J. (1998)  MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.  Science, 281:1668-1671.
  • Nguyen, D. H. D., Catling, A. D., Webb, D. J., Sankovic, M., Walker, L. A., Somlyo, A., Weber, M. J., and Gonias S. L. (1999)  Myosin light chain kinase regulates motility in an integrin-selective manner in urokinase-type plasminogen activator-treated MCF-7 cells.  J. Cell Biol., 146:149-164.
  • Slack, J. K., Catling, A. D., Eblen, S. T., Weber, M. J., and Parsons, J. T. (1999)  c-Raf-mediated inhibition of epidermal growth-factor stimulated cell migration.  J. Biol. Chem., 274:27177-27184.
  • Nguyen, D. H. D., Webb, D. J., Catling, A. D., Song, Q., Dhakephalkar, A., Weber, M.J., Ravichandran, K. S., and Gonias, S. L. (2000)  Urokinase-type plasminogen activator stimulates the extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 migration by a mechanism that requires focal adhesion kinase, Src and Shc.  J. Biol. Chem., 275:19382-19388.
  • Eblen, S. T., Catling, A. D., Assanah, M. C., and Weber, M. J. (2001)  Biochemical and biological functions of the N-terminal, non-catalytic domain of Extracellular-Signal Regulated Kinase 2.  Mol. Cell. Biol., 21:249-259.
  • Catling, A. D., Eblen, S. T., Schaeffer, H. J., and Weber, M. J. (2001)  Scaffold-protein regulation of the MAP kinase cascade.  Methods in Enzymology, 332:368-387.
  • Kloth, M. T., Catling, A. D., and Silva, C. M. (2002)  Novel activation of STAT5b in response to epidermal growth factor.  J. Biol. Chem., 277: 8693-8701.
  • Gioeli, D., Ficarro, S. B., Kwiek, J. J., Aaronson, D., Hancock, M., Catling, A. D., White, F. M., Christian, R. E., Settlage, R. E., Shabanowitz, J., Hunt, D. F. and Weber,M. J.(2002)  Androgen receptor phosphorylation: Regulation and identification of the phosphorylation sites.  J. Biol. Chem.  277: 29304-29314.
  • Eblen, S. T., Slack, J. K., Weber, M. J., and Catling, A. D. (2002).  Rac-PAK Signaling stimulates ERK activation by regulating formation of MEK1-ERK complexes.   Mol. Cell. Biol., 22:6023-6033. 
  • Slack-Davis, J. K., Eblen, S. T., Zecevic, M., Tarcsafalvi, A.., Boerner, S. A., Diaz, H. B., Marshall, M. S., Weber, M. J., Parsons, J. T., and Catling, A. D.  (2003).  PAK1 phosphorylation of MEK1 regulates Fibronectin-stimulated MAPK activation.  Journal of Cell Biology, 162:281-291.
  • Eblen, S. T., Slack-Davis, J. K., Tarcsafalvi, A., Parsons, J. T., Weber, M. J., and Catling, A. D. (2004).  Mitogen-activated kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion.   Mol. Cell. Biol., 24:2308-2317.
  • Sharma, C., Vomastek, T., Catling, A. D., Schaeffer, H.-J., Eblen, S. T. and Weber, M. J.  (2005)  MEK Partner 1 (MP1):  regulation of oligomerization in MAP Kinase signaling.  J. Cell. Biochem., 94:708-719.  
  • Pullikuth, A. K., McKinnon, E., Schaeffer, H. –J., and Catling, A. D.  (2005)  The MEK1 scaffolding protein regulates focal adhesion turnover by integrating PAK1 and Rho signals.  Mol. Cell. Biol., 25:5119-5133.
  • Park, E., Eblen, S. T. and Catling, A. D.  A novel mechanism for MEK1 activation.  Cellular Signalling, in press..
  • Pullikuth, A. K. and Catling, A. D.  MAP kinase scaffolds and cytoskeletal reorganization.  Invited review for Cellular Signalling, in preparation.

 

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YiPing Chen, Ph.D.

Professor of Cell and Molecular Biology
TCC Associate Member
ychen@tulane.edu
Homepage: www.tulane.edu/~chenhome/index.htm
(504) 865-5587, (504) 865-6785 fax
2000 Stern Hall, 6400 Freret St., New Orleans, LA 70118


Biographical Narrative:

Dr. Chen received his B.S. in Biology in 1982 and M.S. in Developmental Biology in 1985 from Fujian Normal University in China. He then received his Ph.D. in Developmental Biology from the University of Iowa in 1993. After postdoctoral training with his Ph.D. mentor Dr. Michael Solursh at the University of Iowa, he carried out further postdoctoral studies with Dr. Richard Maas at the Harvard Medical School where he was promoted to Instructor in Medicine in 1996. In 1997 Dr. Chen took an Assistant Professor position in the Department of Cell and Molecular Biology, Tulane University. He was promoted to Associate Professor and appointed as Director of Division of Developmental Biology in 2001. Dr. Chen's Research focuses on the genetic control of vertebrate organogenesis. His particular interests include the role of homeobox genes and growth factors in the epithelial-mesenchymal interactions that lead to organ formation. One major project studies molecular mechanisms of tooth initiation and patterning. Currently, the project involves identifying genes involved in vertebrate tooth initiation and their expression regulation, studying the origin of tooth developmental potential, studying the patterning of incisor and molar teeth and genes involved in this process and studying the molecular basis of recombinant tooth formation (a model for tooth regeneration). Dr. Chen's research also studies the molecular basis of non-syndromic cleft palate caused by gene mutations in mammals. Cleft palate is one of the most frequent congenital birth defects in human being. It occurs annually with a frequency of 1 in 700 to 1,000 live births among individuals of European descent. Non-syndromic cleft palate arises from genetic or environmental perturbation in the multi-step process of palate development. Similar to human beings, mutations in the Msx1 gene cause non-sydromic cleft palate in mice. The lab is currently examining the role of Msx1, Dlx1, Dlx2, Bmps, Shh and Fgfs in mouse palatogenesis. Dr. Chen's work includes research on the molecular basis of situs inversus in vertebrate animals. Situs inversus occurs with a frequency of one out of 8,000 live births in humans. It was just recently demonstrated that positioning of internal organs is regulated by a cascade of genetic pathways involving a number of genes. Dr. Chen's lab has been studying the role of transcription factor Pitx2 in the regulation of heart looping. They have recently cloned two novel genes in the chick that show a potential involvement in left-right asymmetric determination during early embryonic development. Functional analyses of these two genes are in progress.



Selected Publications:
  • St. Amand TR, Zhang YD, Semina E, Hu YP, Zhao X, Murray J, Chen YP. Antagonistic signals between BMP4 and FGF8 define the expression of Pitx1 and Pitx2 in mouse tooth forming anlage. Dev Biol 217: 323-332 (2000)
  • Zhang ZY, Yu XY, Zhang YD, Geronimo B, Lovlie A, Fromm SH, Chen YP. Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation and duplication and posterior transformation of digit in mouse limb. Dev Biol 220: 154-167 (2000)
  • Chen YP, Zhang YD, Jiang T-X, Barlow AJ, St. Amand TR, Hu YP, Heaney S, Francis-West P, Chuong C-M, Maas M. Conservation of early odontogenic signaling pathways in Aves. Proc Natl Acad Sci USA 97: 10044-10049 (2000)
  • Zhao X, Zhang ZY, Song YQ, Zhang X, Zhang YD, Hu YP, Fromm SH, Chen YP. Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. Mech Dev 99: 29-38 (2000)
  • Yu XY, St. Amand TR, Wang S, Li G, Zhang YD, Hu YP, Nguyen L, Qiu MS, Chen YP. Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick. Development 128: 1005-1013 (2001)
  • Wang SS, Yu XY, Zhang T, Zhang XY, Zhang ZY, Chen YP. Chick Pcl2 regulates the left- right asymmetry by repressing Shh expression in Hensen's node. Development 131, 4381-4391 (2004)
  • Alappat S, Zhang ZY, Suzuki K, Zhang XY, Liu HB, Jiang RL, Yamada G, Chen YP. The cellular and molecular etiology of cleft secondary palate in Fgf10 mutant mice. Dev Biol 277, 102-113 (2005)

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Ernest Chiu, M.D.

Associate Professor of Surgery
Director of Plastic Surgery Research
TCC Associate Member
eschiu@tulane.edu
(504) 988-5500 office, (504) 988-3740 fax
1415 Tulane Ave., New Orleans, LA 70112-2699

 

Degree:
B.A. University of California at Berkeley, 1989
M.D. Columbia University College of Physicians and Surgeons, 1995

Residency:

General Surgery, New York University Medical Center, 1998

Fellowship:

Plastic Surgery, NYU Institute of Reconstructive Plastic Surgery, 2003

Research and Clinical Fellowships:

Post-Doctoral Research Fellow, Skirball Biomolecular Institute, NYUMC, 2000
Microsurgery/Breast Reconstruction Fellow, Memorial-Sloan Kettering Cancer Center, 2004

Certification:

American Board of Plastic Surgery, Certified 2005

Clinical Interests:

  • Head and Neck Reconstruction
  • Aesthetic Surgery
  • Breast Reconstruction
  • Adipocyte and Bone Marrow Derived Stem Cell Research
  • Tissue Engineering
  • Vascular and Bone Biology
  • Facial Paralysis
  • Periorbital Anatomy

Lecture Titles:

2007 Tulane School of Medicine Surgery Grand Rounds
New Orleans, LA
"Microsurgical Oncologic Reconstruction"

2007 Tulane School of Medicine
New Orleans, LA
"Breast Reconstruction"

2007 Tulane School of Medicine Surgery Grand Rounds
New Orleans, LA
"Oncologic Reconstruction using Microsurgical Techniques"

2007 Tulane School of Bioengineering
New Orleans, LA
"Current Application of Biological Scaffolds in Surgery"

2008 Aesthetic Facial Reconstruction Meeting
Tucson, AZ
"Head & Neck Oncologic Reconstruction using Supraclavicular Artery Flap"

2008 Southeastern Society Plastic Surgeons Meeting
Boca Raton, FL
"Head & Neck Oncologic Reconstruction using Supraclavicular Artery Flap"

2008 7th International Head and Neck Society Meeting
San Francisco, CA
"Head & Neck Oncologic Reconstruction using Supraclavicular Artery Flap"



Biographical Narrative:

Dr. Chiu received his M.D. in 1995 from Columbia University in New York. He completed his General Surgery residency in 1996 at New York University Medical Center. Following his General Surgery residency, Dr. Chiu completed a Plastic Surgery residency in 2003 at the Institute of Reconstructive Plastic Surgery in New York. In addition, Dr. Chiu was a post-doctoral research fellow at the Skirball Biomolecular Institute at New York University Medical Center from 1998-2000 as well as completing a fellowship in Microsurgery/Breast Reconstruction at Memorial-Sloan Kettering Cancer Center from 2003-2004.

Dr. Chiu has active ongoing research projects and interests including head and neck reconstruction, adipocyte and bone marrow derived stem cells, tissue engineering, vascular and bone biology, facial paralysis, breast reconstruction, aesthetic surgery, and periorbital anatomy.

Clinic Schedule and Location:

Tulane-Downtown
Plastic Surgery Clinic
1415 Tulane Ave., 6th Floor
New Orleans, LA 70112
Wednesday, 2:00 p.m. - 4:30 p.m.
504-988-1254

Tulane-Downtown
Wound Care Clinic
1415 Tulane Ave., 6th Floor
New Orleans, LA 70112
Every 3rd Monday, 10:00 a.m. - 12:00 p.m.
504-988-1254

Children's Hospital of New Orleans
Pediatric Plastic Surgery Clinic
200 Henry Clay Ave.
New Orleans, LA 70118
Every 3rd Wednesday, 9:00 a.m. - 12:00 p.m.
504-896-2838

Recent Publications:

  • Granzow, J.W., Levine, J.L., Chiu, E.S., Allen, R.J. Breast reconstruction with the deep inferior epigastric perforator flap: J Plast Reconstr Aesthet Surg 59(6): 571-9, 2006.
  • Granzow, J.W., Levine, J.L., Chiu, E.S., Allen, R.J. Breast reconstruction with gluteal artery perforator flaps. J Plast Reconstr Aesthet Surg 59(6): 614-21, 2006.
  • Chiu, E.S., Jelks, E.B., Capel B., Press, R., Aston, S., Jelks, G.W. Successful management of orbital cellulitis and temporary visual loss after blepharoplasty Plast Reconstr Surg 118(3): 67e-72e, 2006.
  • Granzow, J.W., Levine, J.L., Chiu, E.S., Allen, R.J. Breast Reconstruction using Perforator Flaps. Journal of Surgical Oncol 94(6): 441-54, 2006.
  • Chiu, E.S., Baker, D.C. Endoscopic Forehead Rejuvenation I: Limitations, Flaws, and Rewards, Letter Reply Plast Reconstr Surg 119(3): 1115-1117, 2007.
  • Gautam, A., Allen, R.J., LoTempio, M.M., Mountcastle, T., Levine, J.L, Allen, R.J., Chiu, E.S. Congenital Breast Deformity Reconstruction using Perforator Flaps. Annals Plast Surg 58(4): 353-358, 2007.
  • Chiu, E.S., Allen, R.J. "Double-pedicle Abdominal Perforator Free Flaps for Unilateral Breast Reconstruction: New Horizons in Microsurgical Tissue Transfer to the Breast. Discussion" J Plast Reconstr Aesthetic Surg 60(8):913-4, 2007.
  • Bolling, R.P. Sabeeh, V., Stewart, JM, Newsome, R.E., Chiu, E.S., Moses, M. H., Ankyloglossum superius syndrome: diagnosis and surgical management. J Craniofac Surg 18(5): 1094-7, 2007.
  • Chiu, E.S., Bravo, F.G., Siebert, J.W. Transverse Thoracodorsal Artery Perforator Flaps: Experience with 31 Free Flaps. J Plast Reconstr Aesthetic Surg, Dec 2007.
  • Nelson, P.S., Bourgeois, K.M., Nicotri, T. Chiu, E.S., Poole, J. Sclerosing Sweat Duct Carcinoma in a Six Year-Old African American Child Pediatric Dermatology 25(1): 38-42, 2008.
  • Altman, A.M., Matthias, N., Yan, Y., Song, Y.H., Bai, X. Chiu, E.S., Slakey, D.P., Alt, E.U. Dermal matrix as a carrier for in vivo delivery of human adipose-derived stem cells. Biomaterials 29(10): 1431-1442, 2008.

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Timothy S. Church
Professor

Positions and Employment:

  • 1997-1998 Transitional Medicine Residency, Presbyterian-St. Luke Hospital, Denver
  • 1998-2000 Tulane Medical Center Preventive Medicine Residency Program
  • 1999 Chief Resident, Tulane Medical Center Preventive Medicine Residency
  • 2000-2002 Medical/Laboratory Director, The Cooper Institute, Dallas, TX
  • 2002-2006 Vice President, Medical/Laboratory Research, The Cooper Institute, Dallas, TX
  • 2006-present Professor, John S. McIllhenny Endowed Chair of Health Wisdom, Director of Laboratory of Preventive Medicine Research Center, Pennington Biomedical Research, Baton Rouge, LA

Selected Publications:

  • hurch, T.S., Gibbons, L.W., Kampert, J.B., Barlow, C.E., and Blair, S.N. Usefulness of cardiorespiratory fitness as a predictor of all-cause and cardiovascular disease mortality in men with systemic hypertension. American Journal of Cardiology 88 (2001); 651-656.
  • Church T.S., Kampert, J.B., Wilkinson, W.J, Dunn, A.L., Blair, S.N. Evaluating the reproducibility and validity of the Aerobic Adaptation Test. Medicine and Science in Sports and Exercise 33:10 (2001); 1770-1773.
  • Church, T.S., Lavie, C.J., Milani, R.V., Kirby, G.S. Improvements in blood rheology following cardiac rehabilitation and exercise training in patients with coronary heart disease. American Heart Journal 143:2 (2002); 349-355.
  • Church, T.S., Finley,C.E., Kampert, J.B, Gibbons, L.W., Blair, S.N. Relative associations of fitness and fatness to fibrinogen, white blood cell count, uric acid and metabolic syndrome. International Journal of Obesity Research 26:6 (2002); 805-13.
  • Church, T.S., Barlow, C.E., Earnest, C.P., Kampert, J.B., Priest, E.L., Blair, S.N. Associations of cardiorespiratory fitness to C-reactive protein in healthy men. Arteriosclerosis, Thrombosis, Vascular Biology, 22(2002); 1869 - 1876
  • Cheng, YJ, Macera, CA, Church, TS, Blair, SN. Heart rate reserve as a predictor of cardiovascular and all-cause mortality in men Medicine and Science in Sports and Exercise 34:12(2002); 1873-1878
  • Nguyen-Duy, TB, Nichaman, MZ, Church,TS, Blair, SN, Ross R. Visceral fat and liver fat are independent predictors of metabolic risk factors in men. Am J Physiol Endocrinol Metab 2003;284(6):E1065-71
  • Cheng YJ, Lauer MS, Earnest CP, Church TS, Kampert JB, Gibbons LW and Blair SN; Heart Rate Recovery Following Maximal Exercise Testing as a Predictor of Cardiovascular Disease and All-Cause Mortality in Men with Diabetes. Diabetes Care 2003 Jul;26(7):2052-7
  • Cheng YJ, Church TS, Kimball TE, Nichaman MZ, Levine BD, McGuire DK, and Blair SN. Coronary Artery Calcium Detected by Electron Beam Tomography and its Association with Coronary Heart Disease in 17,967 Women and Men. Am Journal of Cardiology 2003 Sep 1;92(5):498-503
  • Church TS, Earnest CP, Wood KA and Kampert JB. Reduction of C-reactive protein concentrations through use of a multivitamin. Am Journal of Medicine 2003 Dec 15; 115(9):702-707
  • Church TS, Cheng YJ, Earnest CP, Barlow, C.E., Gibbons, L.W., Priest, E.L., Blair, S.N. Exercise Capacity and Body Composition as Predictors of Mortality among Men with Diabetes. Diabetes Care 2004 Jan; 27(1): 83-88
  • Wong, S, Katzmarzyk,PT, Nichaman, MZ, Church,TS, Blair, SN, Ross R. Cardiorespiratory fitness is associated with lower abdominal adiposity independent of body mass index in men. Medicine and Science in Sports and Exercise 2004 Feb; 36(2): 286-291
  • Jurca R, Church TS, Jordan AN, Morss GM, Earnest CP. Eight Weeks of Moderate Intensity Exercise Training Increases Heart Rate Variability in Sedentary Postmenopausal Women. Am Heart Journal 2004 May;147(5):e21
  • Katzmarzyk PT, Church TS and Blair SN. Cardiorespiratory Fitness Attenuates the Effects of the Metabolic Syndrome on All-Cause and Cardiovascular Disease Mortality in Men. Archives of Internal Medicine 2004 May 28;164(10): 1092-1097
  • Kuk JL, Nichaman M, Church TS, Blair SN, and Ross R. Liver fat is not a marker of metabolic risk in lean premenopausal women. Metabolism. 2004 Aug;53(8):1066-71.
  • Jurca R, LaMonte MJ, Church TS, Earnest CE, FitzGerald SJ, Barlow CE, Jordan AN, Kampert JB, Blair SN. Associations of Muscle Strength and Aerobic Fitness with Metabolic Syndrome in Men. Med Sci Sports Exerc Med Sci Sports Exerc. 2004 Aug;36(8):1301-1307
  • Katzmarzyk PT, Church TS, Janssen I, Ross R, and Blair SN. Metabolic Syndrome, Obesity and Mortality: Impact of Cardiorespiratory Fitness. Diabetes Care 2005 Feb; 28(2): 391-397
  • Lee SJ, Kuk JL, Katzmarzyk PT, Blair SN, Church TS, Ross R. Cardiorespiratory Fitness Attenuates Metabolic Risk Independent of Abdominal Subcutaneous and Visceral Fat in Men. Diabetes Care 2005 Apr; 28(4):895-901
  • Church TS, Willis MS, Priest EL, Lamonte MJ, Earnest CP, Wilkinson WJ, Wilson DA, Giroir BP. Obesity, macrophage migration inhibitory factor, and weight loss. Int J Obes Relat Metab Disord. 2005 Jun;29(6):675-81.
  • LaMonte MJ, Barlow CE, Jurca R, Kampert JB, Church TS, and SN Blair Cardiorespiratory Fitness Is Inversely Associated With The Incidence Of Metabolic Syndrome. A 6-Year Prospective Study of Men and Women. Circulation. 2005;112; 505-512.
  • Ardern C.I., P.T. Katzmarzyk, I. Janssen, T.S. Church and S.N. Blair. Revised Adult Treatment Panel III Guidelines and Cardiovascular Disease Mortality. Circulation. 2005 Sep 6;112(10):1478-85..
  • LaMonte MJ, FitzGerald SJ, Church TS, Wright CB, Radford NB, Levine BD, Pippin JJ, Gibbons LW, Blair SN and, Nichaman MZ. Coronary Artery Calcium Score Predicts Coronary Heart Disease Events in a Large Cohort of Asymptomatic Men and Women. Am J Epidemiol. 2005 Sep 1;162(5):421-9
  • Janssen I, Katzmarzyk PT, Church TS, and Blair SN. Development of a Clinical Score Sheet for Predicting All-Cause Mortality in Men: The Cooper Clinic Mortality Risk Index. AJPM. 2005 Oct;29(3):194-203.
  • Jurca R, Jackson AS, Lamonte MJ, Morrow JR Jr, Blair SN, Wareham NJ, Haskell WL, van Mechelen W, Church TS, Jakicic JM, Laukkanen R. Assessing cardiorespiratory fitness without performing exercise testing. Am J Prev Med. 2005 Oct;29(3):185-93
  • Church TS, LaMonte MJ, Barlow CE, and Blair SN. Cardiorespiratory Fitness and Body Mass as Predictors of Cardiovascular Disease Mortality among Men with Diabetes. Archives of Internal Medicine. 2005 Oct 10;165(18):2114-20.
  • Jurca R, Lamonte MJ, Barlow CE, Kampert JB, Church TS and Blair SN. Association of muscular strength with incidence of metabolic syndrome in men. Med Sci Sports Exerc. 2005 Nov;37(11):1849-55.
  • Davidson LE, Kuk JL, Church TS, and Ross R. Protocol for Measurement of Liver Fat by Computed Tomography. J Appl Physiol. 2005 Nov 17
  • Katzmarzyk PT, Janssen I, Church TS, Ross R and Blair SN. The Importance of Waist Circumference in the Definition of Metabolic Syndrome: Prospective Analyses of All-cause and CVD Mortality in Men. Diabetes Care. 2006 Feb;29(2):404-409.
  • Kuk JL, Church TS, Blair SN, Ross R. Does measurement site for visceral and abdominal subcutaneous adipose tissue alter associations with the metabolic syndrome? Diabetes Care. 2006 Mar;29(3):679-84.
  • Kuk JL, Katzmarzyk PT, Nichaman MZ, Church TS, Blair SN, Ross R. Visceral fat is an independent predictor of all-cause mortality in men. Obesity. 2006 Feb;14(2):336-41.
  • Church TS, Kuk JL, Ross R, Priest EL, Biltoff E & Blair SN. Association of Cardiorespiratory Fitness, Body Mass Index and Waist Circumference to Nonalcoholic Fatty Liver Disease. Gastroenterology. 2006 Jun;130(7):2023-30.
  • LaMonte MJ, Fitzgerald SJ, Levine BD, Church TS, Kampert JB, Nichaman MZ, Gibbons LW, Blair SN. Coronary artery calcium, exercise tolerance, and CHD events in asymptomatic men. Atherosclerosis. 2006 Nov:189(1):157-62.
  • Trivedi MH, Greer TL, Grannemann BD, Church TS, Galper DI, Sunderajan P, Wisniewski SR, Chambliss HO, Jordan AN, Finley C, Carmody TI. TREAD: Treatment with Exercise Augmentation for Depression: study rationale and design. Clin Trials. 2006;3(3):291-305.
  • Church TS, Levine BD, McGuire DK, LaMonte MJ, Fitzgerald SJ, Cheng YJ, Kimball TE, Blair SN, Gibbons LW, Nichaman MZ. Coronary artery calcium score, risk factors, and incident coronary heart disease events. Atherosclerosis. 2007 Jan;190(1):224-31.
  • McMillan KP, Kuk JL, Church TS, Blair SN, Ross R. Independent associations between liver fat, visceral adipose tissue, and metabolic risk factors in men. Appl Physiol Nutr Metab. 2007 Apr;32(2)265-72.
  • Otto MW, Church TS, Craft LL, Greer TL, Smits JA, Trivedi MH. Exercise for mood and anxiety disorders. J Clin Psychiatry. 2007 May;68(5):669-76.
  • Church TS, Earnest CP, Skinner JS, and Blair SB. Effects of Different Doses of Physical Activity on Cardiorespiratory Fitness Among Sedentary, Overweight or Obese Postmenopausal Women with Elevated Blood Pressure: A Randomized Controlled Trial. JAMA. 2007 May;16(297):2081-91.
  • Janiszewski PM, Oeffinger KC, Church TS, Dunn AL, Eshelman DA, Victor RG, Brooks S, Turoff AJ, Sinclair E, Murray JC, Bashore L, Ross R. Abdominal Obesity, Liver Fat and Muscle Composition in Survivors of Childhood Acute Lymphoblastic Leukemia. J Clin Endocrinol Metab. 2007 Jul 24. (in print)
  • Earnest CP, Mikus CR, Lemieux I, Arsenault BJ, Church TS. Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease. Nutrition. 2007 Sep;23(9):625-33.
  • Rankinen T, Church TS, Rice T, Bouchard C, Blair SN. Cardiorespiratory Fitness, BMI, and Risk of Hypertension: The HYPGENE Study. Med Sci Sports Exerc. 2007 Oct;39(10):1687-1692.

 

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David H. Coy, Ph.D.

Research Professor of Medicine: Section of Endocrinology
Adjunct Professor of Biochemistry Head of Peptide Research Laboratories
Endowed Chair of Peptide and Protein Research
TCC Program Member
dcoy@tulane.edu
(504) 988-3584, (504) 988-3586 fax
1430 Tulane Ave., Box SL-12, New Orleans, LA 70112-2699



Biographical Narrative:

Dr. Coy received his B.S. in Chemistry in 1966 and Ph.D. in organofluorine chemistry in 1969 from the University of Manchester Institute of Science and Technology. He then did postdoctoral research on neurophysin proteins while working with Dr. Murray Saffran's group at the Medical College of Ohio at Toledo and on the synthesis and medicinal chemistry of hypothalamic peptide hormones while working with Nobel Laureate Dr. Andrew Schally at Tulane. He became Assistant Professor in the Department of Medicine at Tulane in 1973 and Research Professor in 1982. Dr. Coy is the author and co-author of over 600 scientific papers. He is a fellow of the American Association for the Advancement of Science, serves on the editorial boards of several journals and has served on study sections for both the NIH and the Medical Research Council of Canada. Dr. Coy's research group has long been prominent in the area of peptide-based drug development. He holds over 50 patents in the area and has successfully brought two peptide analogs to market. Current research interests include the development of receptor antagonists for the bombesin receptors 1 and 3, which are of potential use in inflammatory lung disease and lung cancer, as well as development of urotensin II antagonists of potential therapeutic value in the cardiovascular area. Dr. Coy's group is also researching the use of peptide agonist analogs, particularly somatostatin and bombesin, for the specific targeting and proactive internalization of cytotoxic agents and anti-sense oncogene constructs into tumor cells which heavily over-express receptors for several families of peptides. His group has the capability of conducting peptide-based drug design by classical structure-activity studies, by computer-based design strategies, and, more recently, by combinatorial synthesis of peptidomimetic libraries. His research has been supported by NIH, private industry and the Tulane Peptide Research Fund.


Selected Publications:
  • Tokita K, Hocart SJ, Katsuno T, Mantey SA, Coy DH, Jensen RT. Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368. J Biol Chem 276: 495-504 (2001)
  • Rajaswaran WG, Hocart SJ, Murphy WA, Taylor JE, Coy DH. Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist. J Med Chem 44: 1305-1311 (2001)
  • Rajaswaran WG, Hocart SJ, Murphy WA, Taylor JE, Coy DH. N-methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity. J Med Chem 44: 1416-1421 (2001)
  • Weber HC, Walters J, Leyton J, Casibang M, Purdom S, Jensen RT, Coy DH, Ellis C, Clark G, Moody TW. A bombesin receptor subtype-3 peptide increases nuclear oncogene expression in a MEK-1 dependent manner in human lung cancer cells. "Eur J Pharmacol 412: 13-20 (2001)
  • Mantey SA, Coy DH, Pradhan TK, Igarashi H, Rizo IM, Shen L, Hou W, Hocart SJ, Jensen RT. Rational design of a peptide agaonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3. J Biol Chem 276: 9219-9229 (2001)
  • Sun L, Vasilevich NI, Fuselier JA, Coy DH. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Res 24: 179-186 (2004).
  • Sun L, Fuselier JA, Coy DH. Effects of camptothecin conjugated to a somatostatin analog on growth of tumor cell lines in culture and related tumors in rodents. Drug Deliv, 11: 1-8 (2004).

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